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Cat. No. Product Name Target Signaling Pathways
T61054 Type II topoisomerase inhibitor 1

Type II topoisomerase inhibitor 1 可用于抗菌领域。Type II topoisomerase inhibitor 1 是大肠杆菌DNA 旋转酶的选择性抑制剂,IC50值为 1.7 nM,并能与 Asp73 残基形成氢键。Type II topoisomerase inhibitor 1 抑制拓扑异构酶 IV 的活性,IC50值为 0.98 μM。
T61283 Topoisomerase II inhibitor 3

Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative that acts as a Type II DNA topoisomerase (topo II) inhibitor. It specifically inhibits the topo IIα/β subtypes, with an IC50 value of 0.17 μM for topo IIα and 0.23 μM for topo IIβ. This compound elicits significant DNA damage and induces apoptosis by triggering the loss of mitochondrial membrane potential [1].

化合物

Type II topoisomerase inhibitor 1
Cat.No: T61054
Synonym:
Target:
Topoisomerase II inhibitor 3
Cat.No: T61283
Synonym:
Target:
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