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Cat. No.	Product Name	Target	Signaling Pathways
T13224	Tubulin inhibitor 6 iHAP1	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 6 (iHAP1) 是一种微管蛋白抑制剂，抑制微管蛋白聚合，IC50为 0.87 μM。它抑制多种癌细胞系，抑制 K562 细胞生长，IC50为 840 nM。
T39139	PARP1-IN-6 PARP1-IN-6
	PARP1-IN-6 is a dual tubulin/PARP-1 inhibitor with IC 50 values of 0.94 and 0.48 μM, respectively.
T61532	Tubulin polymerization-IN-6
	Tubulin polymerization-IN-6 (compound 5f) is a potent inhibitor of tubulin polymerization, with an IC50 of 1.09 μM. It not only inhibits cell migration and tube formation but also has anti-angiogenic properties. Additionally, Tubulin polymerization-IN-6 has been found to effectively hinder tumor growth in HT29 xenograft Balb/c nude mice [1].
T74003	HDAC3/6-IN-2
	HDAC3/6-IN-2 (化合物 15) 是一种高效的HDAC6和HDAC3抑制剂，IC50值分别为0.368 μM和0.635 μM。此化合物不仅具备抗肿瘤活性，能够诱导癌细胞凋亡，同时通过降低HDAC6和HDAC3水平，与H3乙酰化和α-微管蛋白的上调有关。
T36199	AZD 1152 (hydrochloride)
	AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM).1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis.2,3AZD 1152 inhibits tumor xenograft growthin vivo.4,5 1.Mortlock, A.A., Foote, K.M., Heron, N.M., et al.Discovery, synthesis, and in vivo activity of a new class of p...