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Cat. No.	Product Name	Target	Signaling Pathways
T1710	Trolox	Apoptosis; Antioxidant; Ferroptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Trolox 是一种维生素 E 的类似物，具有强大的抗氧化作用。它还是强大的膜损伤抑制剂。
T12816	(S)-Trolox	Others	Others
	(S)-Trolox, an analogue of vitamin E, substitutes the phytyl chain with a carboxyl group. This compound serves as a model substance in structural studies and as a standard for assessing antioxidant activity. Moreover, (S)-Trolox exhibits potent and specific neuroprotective and antioxidant properties.
T12645	(R)-Trolox	Others	Others
	(R)-Trolox is a water soluble vitamin E analogue and a competitive tyrosinase inhibitor (Ki value of 0.83 mM and a ID50 value of 1.88 mM).
T38013	Sonlicromanol hydrochloride
	Sonlicromanol hydrochloride (KH176), a derivative of Trolox, is a ROS-redox modulator that effectively crosses the blood-brain barrier. It is specifically employed in the investigation of mitochondrial disorders[1].
T36500	Cyanidin 3-O-arabinoside
	Cyanidin 3-O-arabinoside is an anthocyanin antioxidant that has been found in eggplant. It scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.
T83816	Cytidine-5'-O-(2-thiodiphosphate) sodium CDP-β-S
	Cytidine-5’-O-(2-thiodiphosphate) (CDP-β-S) 是一种不可水解的CDP衍生物，具有抗氧化活性。在Trolox等效吸收能力(TEAC)测定中，该化合物在5至20 µM的浓度范围内清除自由基。
T83871	Ferroptocide
	Ferroptocide是一种抑制剂，可抑制硫氧还蛋白(Trx)活性，并且是pleuromutilin的衍生物。在20 µM的浓度下，Ferroptocide能够抑制ES-2卵巢癌细胞中的Trx活性，并对ES-2细胞具有细胞毒性(IC50 = 1.6 µM)。5 µM的Ferroptocide能够诱导ES-2细胞发生铁死亡，这一效应可以通过铁螯合剂去铁胺(DFO)、抗氧化剂Trolox或铁死亡抑制剂ferrostatin-1来阻断。在使用免疫完整但非免疫缺陷小鼠的4T1小鼠乳腺癌模型中，每周两次以50 mg/kg剂量给药时，Ferroptocide能够减少肿瘤体积。
T36517	Resveratrol-3-O-sulfate sodium
	Resveratrol-3-O-sulfate is a metabolite of resveratrol . In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 μM) decreases the expression of IL-1α, IL-1β, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and decreases the release of TNF-α and IL-6 to similar levels as resveratrol. It has antioxidant activity in a Trolox assay, dose-dependently decreases growth of Caco-2 colorectal adenocarcinoma cells when used at concentrations ranging from 10 to 100 μM, and induces apoptosis at conc...

化合物

Trolox

Cat.No: T1710

Synonym:

Target: Apoptosis, Antioxidant, Ferroptosis, Reactive Oxygen Species

Sonlicromanol hydrochloride

Cat.No: T38013

Synonym:

Target:

Cyanidin 3-O-arabinoside

Cat.No: T36500

Synonym:

Target:

Cytidine-5'-O-(2-thiodiphosphate) sodium

Resveratrol-3-O-sulfate sodium

Cat.No: T36517

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T35749	Thymohydroquinone Thymoquinol	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Thymohydroquinone (Thymoquinol) 是中药材百里香、牛至和其他唇形科植物中含有的单萜酚类化合物。 Thymohydroquinone 抑制癌细胞生长、减少氧化应激和调节炎症反应，在无细胞实验中清除2,2-二苯基-1-picrylhydrazyl 自由基(IC50 = 2.4 μg/ml)，在浓度为1.6至6.4 μg/ml 的氧自由基吸收能力(ORAC)实验中，它的Trolox 当量值为2.6胸腺对苯二酚对A2780、OVCAR-8和CIS-A2780卵巢癌细胞(IC50分别为3.1、8.9和9.8 μM)和人卵巢永生化上皮细胞(IC50 = 14 μM)的生长有抑制作用，体外对恶性疟原虫也有抑制作用(IC50 = 15.9 μM)。

天然产物

Thymohydroquinone

Cat.No: T35749

Synonym: Thymoquinol

Target: Antioxidant, Reactive Oxygen Species

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