Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6798 |
Tretazicar
5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829 |
DNA Alkylator/Crosslinker; DNA Alkylation | DNA Damage/DNA Repair |
Tretazicar (NSC-115829) 是一种抗肿瘤前药,由 NAD(P)H 醌氧化还原酶 2 激活。它在酶促活化后生成细胞毒性双功能烷基剂,可以形成 DNA-DNA 链间交联。 | |||
T68942 |
Caricotamide
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Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the prodrug tretazicar, NQO2 converts tretazicar to the bifunctional alkylating agent dinitrobenzamide, which is capable of forming a high degree of DNA interstrand cross-links, resulting in the inhibition of DNA replication and the induction of apoptosis. NQO2 has been found to be over... |