Cat. No. | Product Name | Target | Signaling Pathways |
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T72157 |
Topoisomerase II inhibitor 7
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TopoisomeraseII inhibitor 7 (化合物 3a) 作为一种高效的拓扑异构酶IIα亚型抑制剂,展现出3.19 μM的IC50值。其能够诱导细胞周期阻滞与凋亡。 | |||
T6010 |
Idarubicin hydrochloride
盐酸伊达比星,Idamycin,4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl,4-Demethoxydaunorubicin hydrochloride,Idarubicin HCl,伊达比星盐酸盐,Zavedos |
Topoisomerase; Antibacterial; Autophagy; Antifungal | Autophagy; DNA Damage/DNA Repair; Microbiology/Virology |
Idarubicin hydrochloride (Zavedos) 是一种蒽环类抗白血病药物,能抑制细菌和酵母菌生长,还抑制拓扑异构酶 II,干扰 DNA 复制和 RNA 转录。 | |||
T61990 | Topoisomerase I/II inhibitor 3 | ||
Topoisomerase I/II inhibitor 3 (化合物7) 是拓扑异构酶 I (Topo I)和 II (Topo II)的有效双抑制剂。 通过抑制 PI3K/Akt/mTOR 信号通路,Topoisomerase I/II inhibitor 3抑制细胞增殖、侵袭和迁移,诱导细胞凋亡(apoptosis)。Topoisomerase I/II inhibitor 3 在肝癌中具有研究价值。 | |||
T64047 |
Topoisomerase II inhibitor 10
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Topoisomerase II inhibitor 10 是拓扑异构酶II (topoisomerase II) 的有效抑制剂 (IC50: 7.45 μM)。Topoisomerase II inhibitor 10 对 HepG-2、MCF-7 和 HCT-116 细胞表现出良好的抗增殖作用。Topoisomerase II inhibitor 10 能够将 HepG-2 细胞的细胞周期阻滞在 G2-M 期,并诱导其凋亡 (apoptosis)。 | |||
T36695 |
TAS-103
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TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells[1]. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103[2]. TAS-103 inhibits the viability ... | |||
T75303 |
Suramin
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Suramin为一种可逆的,竞争性PTPases抑制剂,有效抑制sirtuins:SirT1(IC50=297 nM),SirT2(IC50=1.15 μM),SirT5(IC50=22 μM)。同时,Suramin作为DNAtopoisomeraseII(IC50=5 μM)的竞争性逆转录酶抑制剂,以及SARS-CoV-2 RdRp有效抑制剂。此外,Suramin还能有效抑制IP5K,具有抗寄生虫、抗肿瘤及抗血管生成的作用。 |