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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T62002	Topoisomerase I inhibitor 7
	Topoisomerase I inhibitor 7 (Compound 8) 是有效的Topoisomerase I 抑制剂。Topoisomerase I inhibitor 7 显著抑制肿瘤生长（高达 79%）。在接受 P388 淋巴瘤移植的小鼠模型中，Topoisomerase I inhibitor 7延长了小鼠寿命（153%）。
T61990	Topoisomerase I/II inhibitor 3
	Topoisomerase I/II inhibitor 3 (化合物7) 是拓扑异构酶 I (Topo I)和 II (Topo II)的有效双抑制剂。通过抑制 PI3K/Akt/mTOR 信号通路，Topoisomerase I/II inhibitor 3抑制细胞增殖、侵袭和迁移，诱导细胞凋亡(apoptosis)。Topoisomerase I/II inhibitor 3 在肝癌中具有研究价值。
T61501	Topoisomerase I inhibitor 5
	Topoisomerase I inhibitor 5 is an efficient inhibitor of topoisomerase I, with an IC50 value. It effectively disrupts DNA and inhibits the activity of topoisomerase I. Moreover, it can induce apoptosis in MCF-7 cells and arrest the cell cycle at the G1 phase. Topoisomerase I inhibitor 5 also exhibits potency in reversing P-gp-mediated resistance to Adriamycin [1].
T61717	Topoisomerase I inhibitor 4
	Topoisomerase I inhibitor 4 (compound 7a) is a potent inhibitor of topoisomerase I activity. It effectively inhibits the proliferation of various cancer cell lines including HepG2, A549, MCF-7, and HeLa, with IC50 values of 1.20 μM, 2.09 μM, 1.56 μM, and 1.92 μM, respectively. Thus, Topoisomerase I inhibitor 4 holds promise for cancer research applications [1].
T74750	NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT
	NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT(化合物I)作为一种拓扑异构酶I抑制剂，通过偶联抗体实现对细胞的靶向传递，展现出良好的体内外ADC活性。
T77873	NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride	Topoisomerase	DNA Damage/DNA Repair
	NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT（化合物I）盐酸盐是一种通过偶联抗体实现靶向细胞传递的拓扑异构酶I抑制剂，显示出优良的体内外ADC活性。
T74751	Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT
	Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (Formula V)，作为抗体偶联药物(ADC)的药物连接体部分，该化合物通过linker与topoisomeraseI抑制剂相连。
T36695	TAS-103
	TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells[1]. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103[2]. TAS-103 inhibits the viability ...

化合物

Topoisomerase I inhibitor 7

Cat.No: T62002

Synonym:

Target:

Topoisomerase I/II inhibitor 3

Cat.No: T61990

Synonym:

Target:

Topoisomerase I inhibitor 5

Cat.No: T61501

Synonym:

Target:

Topoisomerase I inhibitor 4

Cat.No: T61717

Synonym:

Target:

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT

Cat.No: T74750

Synonym:

Target:

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride

Cat.No: T77873

Synonym:

Target: Topoisomerase

Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT

Cat. No.	Product Name	Target	Signaling Pathways
TQ0134	Podocarpusflavone A	Topoisomerase	DNA Damage/DNA Repair
	Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.