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Cat. No. Product Name Target Signaling Pathways
T17002 Tazemetostat hydrobromide

E-7438 hydrobromide,氢溴酸泰泽司他,EPZ-6438 hydrobromide

Histone Methyltransferase Chromatin/Epigenetic
Tazemetostat hydrobromide (E-7438 hydrobromide) 是口服的EZH2选择性抑制剂。它抑制含有 PRC2 复合体的野生型 EZH2 的活性,Ki 为 2.5 nM。它还抑制 EZH1,IC50为 392 nM。
T15240 Tazemetostat trihydrochloride

EPZ-6438 trihydrochloride,E-7438 trihydrochloride

Histone Methyltransferase Chromatin/Epigenetic
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing wild-type EZH2 (Ki: 2.5 nM). It inhibits EZH2 (IC50s: 11 and 16 nM in peptide assay and nucleo
T70588 Tazemetostat HCl

Tazemetostat HCl is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1...
T1788 Tazemetostat

E-7438,EPZ6438

Histone Methyltransferase Chromatin/Epigenetic
Tazemetostat (EPZ6438) 是一种组蛋白甲基转移酶 EZH2 抑制剂 (IC50=11 nM),具有口服活性、选择性和 SAM 竞争性。Tazemetostat 具有抗肿瘤活性,可以用于治疗上皮样肉瘤/滤泡性淋巴瘤。

化合物

Tazemetostat hydrobromide
Cat.No: T17002
Synonym: E-7438 hydrobromide,氢溴酸泰泽司他,EPZ-6438 hydrobromide
Target: Histone Methyltransferase
Tazemetostat trihydrochloride
Cat.No: T15240
Synonym: EPZ-6438 trihydrochloride,E-7438 trihydrochloride
Target: Histone Methyltransferase
Tazemetostat HCl
Cat.No: T70588
Synonym:
Target:
Tazemetostat
Cat.No: T1788
Synonym: E-7438,EPZ6438
Target: Histone Methyltransferase
TargetMol Loading
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