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Search Results for " tacrine "

11

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21439	Tacrine 他克林,CS 12602,Tacrinum,Tetrahydroaminocrine	AChR	Neuroscience
	Tacrine (CS 12602) 一种间接胆碱能激动剂和中枢作用的抗胆碱酯酶。它被批准用于治疗阿尔茨海默病。
T2191	Tacrine hydrochloride (hydrate) Tacrine,他克林盐酸盐水合物,Tacrine hydrochloride hydrate,Tetrahydroaminacrine,Tetrahydroaminoacridine	AChR; AChE	Neuroscience
	Tacrine hydrochloride hydrate (Tetrahydroaminacrine) 是一种乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 的抑制剂，它们的IC50值分别为 31 nM 和 25.6 nM。
T22435	Tacrine hydrochloride 四氢氨基吖啶,盐酸他克林,Tacrine HCl	Others	Others
	Tacrine is a indirect cholinergic agonist and centrally acting anticholinesterase. Tacrine hydrochloride hydrate is an inhibitor of acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.
T22048	bis(7)-Tacrine
	Bis(7)-tacrine dihydrochloride 衍生自 tacrine ，是一种二聚体乙酰胆碱酯酶 (AChE) 抑制剂，具有治疗阿尔茨海默病的潜力。Bis(7)-tacrine dihydrochloride 通过阻断 NMDA 受体防止谷氨酸诱导的神经元凋亡。Bis(7)-tacrine dihydrochloride 是一种有效的 GABAA 受体拮抗剂。
T21556	Hydroxytacrine maleate Velnacrine maleate,HP 029 maleate	AChE	Neuroscience
	Hydroxytacrine maleate (Velnacrine maleate) 是一种胆碱酯酶(cholinesterase) 抑制剂，可增强啮齿动物的记忆力，可用于研究阿尔茨海默型老年性痴呆（SDAT）。
T15132	Dimetacrine Dimethacrine,二甲他林	Others	Others
	Dimetacrine is a useful antidepressant.
T29481	7-Bromotacrine
	7-Bromotacrine is a biochemical.
T15132L	Dimetacrine tartrate Linostil,Istonil,Istonyl,Miroistonil,MO 709
	Dimetacrine tartrate is a tricyclic antidepressant (TCA) used for the therapy of depression in Europe and formerly in Japan.
T35975	6,9-Dichloro-1,2,3,4-tetrahydroacridine
	6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.2,3 1.Recanatini, M., Cavalli, A., Belluti, F., et al.SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylchol...
T73245	AChE-IN-9
	AChE-IN-9 是一种Tacrine 连接乙酰化 β-葡萄糖的糖缀合物。AChE-IN-9 也是一种AChE 抑制剂，IC50为 0.4 μM，对健康细胞的肝毒性低。Tacrine 可用于阿兹海默症的研究。
T63144	ZLMT-12
	ZLMT-12 (compound 35) 是他克宁衍生物，是一种有效的 CDK2 (IC50: 0.011 μM) 和 CDK9 (IC50: 0.002 μM) 抑制剂。ZLMT-12 能够较弱的抑制 AChE (IC50: 19.023 μM) 和 BuChE (IC50: 2.768 μM)。ZLMT-12 具抗增殖活性，且细胞毒性较低。ZLMT-12 能够将细胞周期阻滞在 S 期和 G2/M 期，并诱导细胞凋亡。

化合物

Cat.No: T21439

Synonym: 他克林,CS 12602,Tacrinum,Tetrahydroaminocrine

Target: AChR

Tacrine hydrochloride (hydrate)

Cat.No: T2191

Synonym: Tacrine,他克林盐酸盐水合物,Tacrine hydrochloride hydrate,Tetrahydroaminacrine,Tetrahydroaminoacridine

Target: AChR, AChE

Tacrine hydrochloride

Cat.No: T22435

Synonym: 四氢氨基吖啶,盐酸他克林,Tacrine HCl

Target: Others

bis(7)-Tacrine

Cat.No: T22048

Hydroxytacrine maleate

Cat.No: T21556

Synonym: Velnacrine maleate,HP 029 maleate

Target: AChE

Cat.No: T15132

Synonym: Dimethacrine,二甲他林

Target: Others

Cat.No: T29481

Dimetacrine tartrate

Cat.No: T15132L

Synonym: Linostil,Istonil,Istonyl,Miroistonil,MO 709

6,9-Dichloro-1,2,3,4-tetrahydroacridine

Cat.No: T35975

Cat.No: T73245

Cat.No: T63144

Cat. No.	Product Name	Target	Signaling Pathways
T5S1025	Picfeltarraenin IA 苦玄参苷IA,Picfeltarraenin A,苦玄参苷 IA	AChE	Neuroscience
	Picfeltarraenin IA (Picfeltarraenin A) 是一种Picriafel-terraeLour (P.fel-terrae) 中提取的三萜类化合物，是一种乙酰胆碱酯酶抑制剂。它可用于感染，癌症和炎症的研究。
TN2067	Picfeltarraegenin X 苦玄参苷X,Picfeltarraenin X	AChR	Neuroscience
	Picfeltarraenin X shows stronger AChE inhibition than the known AChE inhibitor Tacrine.
TN4711	Onitin	Others	Others
	Onitin shows super-oxide and DPPH free radical scavenging effects.It also exhibits hepatoprotective activity on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.
TN2487	1,3,5,6-Tetrahydroxyxanthone	Others	Others
	1,3,5,6-Tetrahydroxyxanthone shows moderate hepatoprotective activity with EC(50) values of 160.2 +/- 0.6 microM against tacrine-induced cytotoxicity in HepG2 cells. It can inhibit angiotensin-I-converting-enzyme activity in a dose-dependent manner.
TN5154	Torilolone	Others	Others
	Torilin and torilolone show hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells,the EC50 values are 20.6 +/- 1.86 and 3.6 +/- 0.1 microM, respectively; and silybin as a positive control shows an EC50 value of 69.0

天然产物

Picfeltarraenin IA

Cat.No: T5S1025

Synonym: 苦玄参苷IA,Picfeltarraenin A,苦玄参苷 IA

Target: AChE

Picfeltarraegenin X

Cat.No: TN2067

Synonym: 苦玄参苷X,Picfeltarraenin X

Target: AChR

Cat.No: TN4711

Target: Others

1,3,5,6-Tetrahydroxyxanthone

Cat.No: TN2487

Target: Others

Cat.No: TN5154

Target: Others

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