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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T60061 |
RU-TRAAK-2
|
Potassium Channel | Membrane transporter/Ion channel |
RU-TRAAK-2 是 TWIK 相关的花生四烯酸刺激的 K+ 通道的可逆抑制剂,对包括 Kv1.2、GIRK2 和 Slo1 在内的非 K2P 通道没有活性。 | |||
T10979 |
DCPIB
|
Potassium Channel; Chloride channel | Membrane transporter/Ion channel |
DCPIB 是选择性可逆体积调节性阴离子通道抑制剂,抑制肿胀激活氯电流,在 CPAE 细胞中,IC50值为 4.1 μM。它能够电压依赖性激活钾离子通道 TREK1 和 TRAAK,抑制 TRESK、TASK1 和 TASK3的 IC50值分别为 0.14、0.95 和 50.72 μM。 | |||
T37296 |
GI-530159
|
||
TREK1 and TREK2 channel activator (EC50 = 0.76 μM in Rb efflux assay in TREK1-expressing CHO cells). Exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. Hyperpolarizes membrane potential of dorsal root ganglion neurons and depresses neuronal activity in vitro. Loucif et al (2018) GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability. Br.J.Pharmacol. 175 2272 PMID... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37709 |
2,2,2-Trichloroethanol
|
Potassium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
2,2,2-Trichloroethanol 是非经典的 K2P 通道 TREK-1和 TRAAK 的激动剂。 |