Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14340 |
Atiratecan
TP300 |
Others | Others |
Atiratecan (TP300) is a prodrug of camptothecin analog CH0793076. Atiratecan shows antitumor activity against both breast cancer resistance protein (BCRP)-positive and -negative xenografts in mouse xenograft models[1]. Atiratecan does not inhibit acetylch | |||
T14945 |
CH-0793076
TP3076 |
Topoisomerase | DNA Damage/DNA Repair |
CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein). CH-0793076 inhibits DNA topoisomerase I (IC50: 2.3 μM). | |||
T73672 | CH-0793076 TFA | ||
CH-0793076 (TP3076) TFA,喜树碱的六环类似物,是 TP300 的活性药物和主要代谢物。CH-0793076 TFA 抑制 DNA 拓扑异构酶 I (DNAtopoisomeraseI),IC50为 2.3 μM。CH-0793076 TFA 对表达 BCRP(乳腺癌耐药蛋白) 的细胞也有活性。 |