Cat. No. | Product Name | Target | Signaling Pathways |
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T80971 |
TNIK-IN-6
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TNIK-IN-6 (Compound 9) 是一种Traf2和Nck相互作用激酶(TNIK)的抑制剂,具有0.93 nM的IC50,对神经与精神疾病具有重要影响。 | |||
T36016 |
PF 06260933 dihydrochloride
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MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active. Ammirati et al (2015) Discovery of an in vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatment. ACS Med.Chem.Lett. 6 1128 PMID:26617966 |