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Search Results for " spermine "

19

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12187L	Naspm trihydrochloride 1-Naphthylacetyl spermine trihydrochloride	iGluR	Membrane transporter/Ion channel; Neuroscience
	Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) 是Joro 蜘蛛毒素的合成类似物，具有拮抗CP-AMPA 受体的活性。
T23036	N-(4-Hydroxyphenylacetyl)spermine	Others	Others
	N-(4-Hydroxyphenylacetyl)spermine is a NMDA receptor antagonist.
T12187	Naspm 1-Naphthylacetyl spermine	Others	Others
	Naspm is a synthetic analogue of Joro spider toxin and is a antagonist iscalcium permeable AMPA (CP-AMPA) receptors.
T64076	Spermine Prodrug-1
	Spermine Prodrug-1 是一种氧化还原敏感的精胺前药。Spermine Prodrug-1 对野生型 (CMS-24949) 和精胺合酶基因 (SMS) 突变型 (CMS-26559, 和 CMS-6233) 成纤维细胞具有抑制作用，他们的 IC50 值分别为 326.7, 198.5, 和 244.1 μM。Spermine Prodrug-1 能够用于 Snyder Robinson 综合征的治疗。
T9640	Diethylnorspermine HCl Diethylnorspermine tetrahydrochloride,N1,N11-Diethylnorspermine tetrahydrochloride,DENSPM tetrahydrochloride	Others	Others
	Diethylnorspermine HCl (N1,N11-Diethylnorspermine tetrahydrochloride) 可有效诱导 SSAT (亚精胺/精胺N1-乙酰转移酶) mRNA，并有效稳定 SSAT 酶活性。
T60066	thermospermine N'-[3-(3-aminopropylamino)propyl]butane-1,4-diamine,1,12-Diamino-4,8-diazadodecane	Others	Others
	Thermospermine 是精胺的结构异构体，在抑制木质部分化中发挥作用。Thermospermine 可用于作为植物生长调节剂和控制木材生物质生产的研究。
T36416	N1-Acetylspermine trihydrochloride N1-Acetylspermine (hydrochloride)	Others	Others
	N1-Acetylspermine trihydrochloride 是精胺的单乙酰化衍生物，精胺是一种内源性多胺。 N1-Acetylspermine trihydrochloride 可用于研究人体肉毒碱转运蛋白 SLC22A16 对抗癌多胺类似物博莱霉素 A5 的摄取。
T40887	N1,N12-Diacetylspermine dihydrochloride N1,N12-Diacetylspermine dihydrochloride,Diacetylspermine 2HCl	Endogenous Metabolite	Metabolism
	N1,N12-Diacetylspermine dihydrochloride (Diacetylspermine 2HCl) 是 Spermine 的二乙酰化衍生物。癌症的发生与 N1,N12-Diacetylspermine dihydrochloride 的上调有关，使其成为检测癌症发生的生物标记物。
T60348	N1,N11-Diethylnorspermine
	N1,N11-Diethylnorspermine (DENSPM) 是一种有效的抗癌剂。N1,N11-Diethylnorspermine 是一种精胺类似物,可激活多胺分解代谢。N1,N11-Diethylnorspermine 诱导细胞色素 c 从线粒体中释放，导致 caspase 3的激活。N1,N11-Diethylnorspermine 通过诱导亚精胺/精胺 N1- 乙酰转移酶 (SSAT) 结合产生过氧化氢杀灭多形胶质母细胞瘤 (GBM) 细胞。
T70805	Diethylnorspermine HBr
	Diethylnorspermine, also known as DENSPM, BE-333, DE-333 and N(1),N(11)-Diethylnorspermine, is a highly potent known inducer of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT). A designed polyamines (PAs) analog which induces cell cycle arrest, inhibits proliferation and induces apoptosis in melanoma, breast, prostate, lung and colon cancer cells..
T27171	Diethylhomospermine DEHOP,BE-4-4-4,DEHSPM,DE-444
	Diethylhomospermine is a drug potentially for the treatment of AIDS-related chronic diarrhea.Diethylhomospermine also shows promising anticancer activity.
T130733	N1,N5,N10,N14-Tetra-trans-p-coumaroylspermine
	N1,N5,N10,N14-Tetra-trans-p-coumaroylspermine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T130733。
T73767	N1-Acetylspermine
	N1-Acetylspermine 是存在于尿中的内源代谢物，可用于研究白血病。
T60738	JNJ-1289	Smo	Stem Cells
	JNJ-1289 是一种具有选择性、有效性和竞争性人精胺氧化酶 (hSMOX) 抑制剂，IC50 值为 50 nM。JNJ-1289 具有潜在的抗癌和抗炎活性，可用于研究多胺分解代谢类疾病。
T35878	N-(3-Aminopropyl)cyclohexylamine	Others	Others
	N-(3-Aminopropyl)cyclohexylamine, a derivative of cyclohexylamine, functions as a selective and competitive inhibitor of spermine synthase, making it suitable for research on neurological diseases[1].
T63163	cSPM
	cSPM (Cyclic spermine) 是一种 Aβ42 抑制剂。cSPM 对三种不同肽 Aβ42、胰淀素和胰岛素的聚集具有抑制作用，且能够减少细胞毒性。
T40860	Ivospemin
	Ivospemin is an antineoplastic spermine analog.
T73407	JNJ-9350
	JNJ-9350为spermine oxidase (SMOX)和polyamine oxidase (PAO)的抑制剂，其对SMOX的IC50值为0.01 μM，对PAO的IC50值为0.79 μM。该化合物主要用于癌症研究领域。
T70049	Ro 04-5595 free base
	Ro 04-5595 is a selective antagonist of NMDA receptors NR2B subunits. Ro 04-5595 had an EC 50 of 186 ± 32 nmol/L. Ro 04-5595 was predicted to bind the EVT-101 binding site, not the ifenprodil-binding site. Specific binding, defined with a new NR2B-specific antagonist Ro 04-5595 at 10 microM was fully inhibited by several compounds with the following rank order of affinities--Ro 25-6981 > CP-101,606 > Ro 04-5595 = ifenprodil >> eliprodil > haloperidol > spermine > spermidine > MgCl2 > CaCl2--and...

化合物

Naspm trihydrochloride

Cat.No: T12187L

Synonym: 1-Naphthylacetyl spermine trihydrochloride

Target: iGluR

N-(4-Hydroxyphenylacetyl)spermine

Cat.No: T23036

Target: Others

Cat.No: T12187

Synonym: 1-Naphthylacetyl spermine

Target: Others

Spermine Prodrug-1

Cat.No: T64076

Diethylnorspermine HCl

Cat.No: T9640

Synonym: Diethylnorspermine tetrahydrochloride,N1,N11-Diethylnorspermine tetrahydrochloride,DENSPM tetrahydrochloride

Target: Others

Cat.No: T60066

Synonym: N'-[3-(3-aminopropylamino)propyl]butane-1,4-diamine,1,12-Diamino-4,8-diazadodecane

Target: Others

N1-Acetylspermine trihydrochloride

Cat.No: T36416

Synonym: N1-Acetylspermine (hydrochloride)

Target: Others

N1,N12-Diacetylspermine dihydrochloride

Cat.No: T40887

Synonym: N1,N12-Diacetylspermine dihydrochloride,Diacetylspermine 2HCl

Target: Endogenous Metabolite

N1,N11-Diethylnorspermine

Cat.No: T60348

Diethylnorspermine HBr

Cat.No: T70805

Diethylhomospermine

Cat.No: T27171

Synonym: DEHOP,BE-4-4-4,DEHSPM,DE-444

N1,N5,N10,N14-Tetra-trans-p-coumaroylspermine

Cat.No: T130733

N1-Acetylspermine

Cat.No: T73767

Cat.No: T60738

Target: Smo

N-(3-Aminopropyl)cyclohexylamine

Cat.No: T35878

Target: Others

Cat.No: T63163

Cat.No: T40860

Cat.No: T73407

Ro 04-5595 free base

Cat.No: T70049

Cat. No.	Product Name	Target	Signaling Pathways
T3007	Spermine Gerontine,Musculamine,精胺,4,9-Diaza-1,12-dodecanediamine,NSC 268508,Neuridine	Influenza Virus; Endogenous Metabolite	Metabolism; Microbiology/Virology
	Spermine (Neuridine) 作为一个直接的自由基清除剂，具有抗病毒作用，能够保护 DNA 免受自由基的攻击。
T3093	Spermine tetrahydrochloride 精胺盐酸盐,Spermine Tetrahydrochloride,Neuridine tetrahydrochloride,Musculamine tetrahydrochloride,Gerontine tetrahydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Spermine tetrahydrochloride (Musculamine tetrahydrochloride) 是内源性代谢产物的一种。
T7849	Norspermine	Others	Others
	Norspermine 是一种多胺类似物，用于治疗非小细胞肺癌和乳腺癌。
TQ0308	Castanospermine 1,6,7,8-Tetrahydroxyoctahydroindolizine,栗精胺,亚胺糖栗树精胺,(1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine	Glucosidase	Metabolism
	Castanospermine (1,6,7,8-Tetrahydroxyoctahydroindolizine) 能够抑制α- and β-glucosidases 的所有形式。
T5888	5-Methoxysalicylic acid 5-MeOSA,5-甲氧基水杨酸	Others	Others
	5-Methoxysalicylic acid (5-MeOSA) 是一种天然产物。它同精胺联用后，是低聚核苷酸 MALDI 质谱分析的有效基质。

天然产物

Cat.No: T3007

Synonym: Gerontine,Musculamine,精胺,4,9-Diaza-1,12-dodecanediamine,NSC 268508,Neuridine

Target: Influenza Virus, Endogenous Metabolite

Spermine tetrahydrochloride

Cat.No: T3093

Synonym: 精胺盐酸盐,Spermine Tetrahydrochloride,Neuridine tetrahydrochloride,Musculamine tetrahydrochloride,Gerontine tetrahydrochloride

Target: Others, Endogenous Metabolite

Cat.No: T7849

Target: Others

Castanospermine

Cat.No: TQ0308

Synonym: 1,6,7,8-Tetrahydroxyoctahydroindolizine,栗精胺,亚胺糖栗树精胺,(1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine

Target: Glucosidase

5-Methoxysalicylic acid

Cat.No: T5888

Synonym: 5-MeOSA,5-甲氧基水杨酸

Target: Others

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