3
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T34493 |
Salinosporamide B
|
||
Salinosporamide B is a deschloro analog isolated from the marine Actinomycete Salinispora tropica. | |||
T34494 |
Salinosporamide C
|
||
Salinosporamide C is a decarboxylated pyrrole analogue isolated from the marine Actinomycete Salinispora tropica. | |||
T36869 |
5'-chloro-5'-Deoxyadenosine (hydrate)
|
||
5'-chloro-5'-Deoxyadenosine (hydrate) is a nucleoside analog used as a substrate in polyketide biosynthesis. S-(5'-adenosyl)-L-methionine can be converted to 5'-chloro-5'-deoxyadenosine in a reaction catalyzed by a SAM-dependent chlorinase. Through a 7-step route, 5'-chloro-5'-deoxyadenosine can be converted to chloroethylmalonyl-CoA, which has been shown to be involved in the biosynthesis of the anticancer agent salinosporamide A in the marine bacterium S. tropica. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16012 |
Marizomib
NPI-0052,Salinosporamide A,ML858 |
Proteasome | Proteases/Proteasome; Ubiquitination |
Marizomib (ML858) 是一种新型不可逆的脑渗透性泛蛋白酶体 (proteasome) 抑制剂,对 20S 蛋白酶体的 CT-L (β5)、CT-T-laspase 样 (C-L, β1) 和胰蛋白酶样 (T-L, β2) 具有抑制作用, IC50 分别为 3.5, 28, 430 nM。 |