Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T71223 | SR-33805 | ||
SR-33805 is a calcium channel antagonist potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes. A SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation. D... | |||
T8674 |
SR33805
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
SR33805 是钙通道拮抗剂,在去极化和极化条件下的 EC50值分别为 4.1 和 33 nM。它阻止 L 型 Ca2+通道,可用于研究急性或慢性心脏衰竭。 | |||
T23391 |
SR 33805 oxalate
|
Others | Others |
Ca2+ channel antagonist | |||
T71221 |
CGS 21595
|
||
CGS 21595 inhibits the formation of 5-hydroxyeicosatetraenoic acid and leukotriene B4; rapidly metabolized to CGS 19213. |