Cat. No. | Product Name | Target | Signaling Pathways |
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T5457 |
SN 6
SN6 |
Calcium Channel; Na+/Ca2+ Exchanger | Membrane transporter/Ion channel; Metabolism |
SN 6 (SN6) 是选择性NCX 抑制剂,可抑制 NCX1、NCX2 和 NCX3 对45Ca2+的吸收,IC50值分别为 2.9、16 和 8.6 μM。 | |||
T72929 |
18:0-22:6 DG
1-Stearoyl-2-docosahexaenoyl-sn-glycerol |
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18:0-22:6 DG (1-Stearoyl-2-docosahexaenoyl-sn-glycerol) 是一种二酰基甘油,可以与RasGRP 结合并调节MAP 激酶活化。 | |||
T37119 |
1,2,3-Trioctanoyl-rac-glycerol-13C3
1,2,3-Trioctanoyl-rac-glycerol-13C3 |
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1,2,3-Trioctanoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2,3-trioctanoyl-rac-glycerol by GC- or LC-MS. 1,2,3-Trioctanoyl-rac-glycerol is a triacylglycerol that contains octanoic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trioctanoyl-rac-glycerol increases hippocampal levels of the glycolytic metabolites glucose 6-phosphate, fructose 6-phosphate, and β-hydroxybutyrate and the seizure threshold in the 6 Hz psychomo... | |||
T17730 | CL2 Linker | Others | Others |
CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2]. | |||
T38031 |
(R)-KT109
(R)-KT109 |
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(R)-KT109 is the (R) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (R)-KT109 is an inhibitor of DAGLβ (IC50 = 0.79 nM) and of DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol . It also inhibits α/β-hydrolase domain-containing protein 6 (ABHD6) with an IC50 value of 2.51 nM. (R)-KT109 is more potent at DAGLβ, DAGLα, and ABHD6 than (S)-KT109 . | |||
T38148 |
(S)-KT109
(S)-KT109 |
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(S)-KT109 is the (S) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (S)-KT109 is a less potent inhibitor of DAGLβ (IC50 = 39.81 nM), DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM), and α/β-hydrolase domain-containing protein 6 (ABHD6; IC50 = 630.9 nM) than (R)-KT109 . | |||
T36452 |
1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
|
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1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol . 1-Arachidonoyl lysophosphatidic acid binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS. It also decreases differe... | |||
T36172 |
KOdiA-PC
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Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine, or KOdiA-PC, is one of the most potent CD36 ligands among the oxLDL species. KOdiA-PC confers CD36 scave... |