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Cat. No. | Product Name | Target | Signaling Pathways |
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T9836 |
(E)-SI-2
|
Others | Others |
(E)-SI-2 是类固醇受体 coactivator-3(SRC-3 或 AIB1)的有效小分子抑制剂,可选择性抑制 SRC-3 的内在转录活性,也抑制 SRC-1 和 SRC-2。它选择性地降低 SRC-3 的细胞蛋白水平,但不降低 CARM-1 的细胞蛋白水平,阻断 MDA-MB-468 细胞生长,IC50 值为 3.4 nM,但不影响正常细胞。 | |||
T28773 |
SI-2
SI2,EPH 116,EPH116,EPH-116 |
Others | Others |
SI-2是类固醇受体辅激活因子-3(SRC-3或 AIB1)的抑制剂(SMI)。SI-2可选择性降低细胞中 SRC-3的转录活性和蛋白浓度,并选择性诱导低纳摩尔范围(3-20 nM)内的乳腺癌症细胞死亡,但不影响正常细胞存活率。 | |||
T12906 |
SI-2 hydrochloride
EPH 116 hydrochloride |
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
SI-2 hydrochloride (EPH 116 hydrochloride) 是 SRC-3 的抑制剂,诱导乳腺癌细胞死亡的 IC50 值为 3-20 nM。SI-2 hydrochloride 具有良好的药代动力学特征和改善的毒性,以及可接受的口服可用性。 | |||
T74920 | G12Si-2 | ||
G12Si-2,一种 G12Si-1 的类似物,可作为阴性对照。G12Si-2 不是 KRAS G12S 突变体的共价抑制剂。 | |||
T62378 |
(1R,2R)-ML-SI3
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(1R,2R)-ML-SI3 是一种有效的 TRPML1 (IC50: 1.6 μM)和 TRPML2 (IC50: 2.3 μM) 抑制剂。(1R,2R)-ML-SI3 也是一种 TRPML3 的弱抑制剂,其 IC50 值为 12.5 μM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36226 |
Beauveriolide I
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Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.78 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 6 μM).2 1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific i... | |||
T36227 |
Beauveriolide III
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Beauveriolide III is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.41 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 5.5 μM).2Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic ... |