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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T62404 |
SHMT-IN-2
|
Others | Others |
SHMT-IN-2 (compound 2) 是一种特异性人 SHMT1/2 小分子抑制剂,能够作用于 SHMT1 (IC50: 13 nM) 和 SHMT2 (IC50: 66 nM)。SHMT-IN-2 对许多人类癌细胞的生长具有抑制作用,对 B 细胞淋巴瘤具有敏感性。 | |||
T12897L |
SHIN1
RZ-2994 |
Others | Others |
SHIN1 (RZ-2994) 是一种有效的人丝氨酸羟甲基转移酶1和2抑制剂,体外实验的 IC50分别为5和13 nM。 | |||
T12898 |
(+)-SHIN1
(+)-RZ-2994 |
Others | Others |
(+)-SHIN1 ((+)-RZ-2994) 是 SHIN1 的活性 (+) 对映体。SHIN1 是人丝氨酸羟甲基转移酶1和2 (SHMT1/2) 抑制剂。 | |||
T41297 |
Lometrexol hydrate
|
||
Lometrexol hydrate (DDATHF hydrate) 是一种抗嘌呤类抗叶酸 (antifolate) 药,可抑制甘氨酰胺核糖核苷酸甲酰基转移酶 (GARFT) 的活性,但不会诱导可检测水平的 DNA 链断裂。Lometrexol hydrate 可以进一步抑制嘌呤从头合成,引起异常的细胞增殖和凋亡,甚至细胞周期停滞。Lometrexol hydrate 具有抗癌活性。Lometrexol hydrate 还是一种有效的人丝氨酸羟甲基转移酶 1/2 (hSHMT1/2) 抑制剂。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00484 |
SHMT1 Protein, Human, Recombinant (His)
Serine Methylase,Glycine Hydroxymethyltransferase,Serine Hyd... |
Human | HEK293 Cells |
Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to ... |