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Search Results for " shmt1 "
Targets Recommended: Others

4

抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T62404 SHMT-IN-2

Others Others
SHMT-IN-2 (compound 2) 是一种特异性人 SHMT1/2 小分子抑制剂,能够作用于 SHMT1 (IC50: 13 nM) 和 SHMT2 (IC50: 66 nM)。SHMT-IN-2 对许多人类癌细胞的生长具有抑制作用,对 B 细胞淋巴瘤具有敏感性。
T12897L SHIN1

RZ-2994

Others Others
SHIN1 (RZ-2994) 是一种有效的人丝氨酸羟甲基转移酶1和2抑制剂,体外实验的 IC50分别为5和13 nM。
T12898 (+)-SHIN1

(+)-RZ-2994

Others Others
(+)-SHIN1 ((+)-RZ-2994) 是 SHIN1 的活性 (+) 对映体。SHIN1 是人丝氨酸羟甲基转移酶1和2 (SHMT1/2) 抑制剂。
T41297 Lometrexol hydrate

Lometrexol hydrate (DDATHF hydrate) 是一种抗嘌呤类抗叶酸 (antifolate) 药,可抑制甘氨酰胺核糖核苷酸甲酰基转移酶 (GARFT) 的活性,但不会诱导可检测水平的 DNA 链断裂。Lometrexol hydrate 可以进一步抑制嘌呤从头合成,引起异常的细胞增殖和凋亡,甚至细胞周期停滞。Lometrexol hydrate 具有抗癌活性。Lometrexol hydrate 还是一种有效的人丝氨酸羟甲基转移酶 1/2 (hSHMT1/2) 抑制剂。

化合物

SHMT-IN-2
Cat.No: T62404
Synonym:
Target: Others
SHIN1
Cat.No: T12897L
Synonym: RZ-2994
Target: Others
(+)-SHIN1
Cat.No: T12898
Synonym: (+)-RZ-2994
Target: Others
Lometrexol hydrate
Cat.No: T41297
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPJ-00484 SHMT1 Protein, Human, Recombinant (His)

Serine Methylase,Glycine Hydroxymethyltransferase,Serine Hyd...

Human HEK293 Cells
Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to ...

重组蛋白

SHMT1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00484
Species: Human
Expression System: HEK293 Cells
TargetMol Loading
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