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4

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP2123	ShK-Dap22
	Extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4 and rKV1.2 respectively, and >1000
T80066	ShK toxin	Potassium Channel	Membrane transporter/Ion channel
	ShK toxin 是从加勒比海葵（Stichodactylu helianthus）的全身提取物中分离出的一种蛋白，能够阻断电压依赖性钾通道(Kv1.3 通道)。在竞争实验中，ShK toxin 与树突毒素 I 及α-树突毒素相互竞争，以与大鼠脑突触体膜结合，从而促进乙酰胆碱的释放。此外，ShK toxin 抑制培养的大鼠背根神经节神经元中的K+ 电流，并且能够抑制T淋巴细胞的增殖。
T76280	Dalazatide
	Dalazatide (ShK-186)是一种针对Kv1.3钾通道的特异性肽抑制剂，用于研究多种自身免疫性疾病，包括多发性硬化症(MS)、红斑狼疮、银屑病、类风湿性关节炎、1型糖尿病及炎症性肠病。
T76280L	Dalazatide TFA
	Dalazatide (ShK-186) TFA 是特异性 Kv1.3 钾通道肽抑制剂，适用于研究多发性硬化症 (MS)、红斑狼疮、银屑病、类风湿性关节炎、1型糖尿病及炎症性肠病等自身免疫性疾病。

化合物

Cat.No: TP2123

Cat.No: T80066

Target: Potassium Channel

Cat.No: T76280

Cat.No: T76280L

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04771	CARKL Protein, Human, Recombinant (His & GST) SHK,CARKL,sedoheptulokinase	Human	Baculovirus Insect Cells
	CARKL, also known as SHPK, is a nonprotein kinase of glucose metabolism. CARKL has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. CARKL catalyzes an orphan reaction in the pentose phosphate pathway, refocusing cellular metabolism to a high-redox state upon physiological or artificial downregulation. CARKL-dependent metabolic reprogramming is required for proper M1- and ...
TMPJ-00297	SHPK Protein, Human, Recombinant (His) Carbohydrate kinase-like protein,SHPK,CARKL,Sedoheptulokinas...	Human	HEK293 Cells
	Sedoheptulokinase (SHPK) belongs to the FGGY kinase family, and is mainly located in cytoplasm. SHPK is strongly expressed in liver, kidney and pancreas. It is expressed at lower levels in placenta and heart, and very weakly expressed in lung and brain. SHPK catalyzes the chemical reaction: ATP + sedoheptulose = ADP + sedoheptulose 7-phosphatecan, It can transform sedoheptulose to sedoheptulose 7-phosphate in the condition of ATP, and acts as a modulator of macrophage activation through control ...

重组蛋白

CARKL Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04771

Species: Human

Expression System: Baculovirus Insect Cells

SHPK Protein, Human, Recombinant (His)

Cat.No: TMPJ-00297

Species: Human

Expression System: HEK293 Cells

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