Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12893 |
SGLT inhibitor-1
|
SGLT | GPCR/G Protein |
SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively). | |||
T1766 |
Empagliflozin
BI 10773,恩格列净 |
SGLT | GPCR/G Protein |
Empagliflozin (BI 10773) 是一种 SGLT-2 抑制剂 (IC50=3.1 nM),具有有效的和选择性,对 SGLT-1/4/5/6 的选择性高 300 倍以上。Empagliflozin 可用于治疗二型糖尿病。 | |||
T35619 |
Dapagliflozin-3-O-β-D-Glucuronide
|
||
Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1] Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to dapagliflozin-3-O-β-D-glucuronide, which is 2,600-fold less potent than the parent compound with regard to SGLT2 inhibition.[2] |