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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12819	S130	Cysteine Protease	Proteases/Proteasome
	S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux.
T77920	ZXH-4-130 TFA	PROTACs	PROTAC
	ZXH-4-130 TFA为高效、选择性CRBN降解剂，属于CRBN-VHL类(hetero-PROTAC)化合物。在MM1.S细胞中，10 nM ZXH-4-130 TFA可诱导约80%的CRBN降解。
T61988	Ruxolitinib sulfate
	Ruxolitinib sulfate (INCB018424 sulfate) 是一种有效的JAK1/2抑制剂。Ruxolitinib sulfate 抑制JAK1/2的IC50为 3.3 nM/2.8 nM，高于 JAK3 130 倍。
T35989	CAY10565
	S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10565 is a member of a new class of S-nitrosothiol species that act as NO donors under acidic conditions. It decomposes with a half-life of 130 minutes in 0.1 M phosphate buffer, pH 5.0,...

化合物

Cat.No: T12819

Target: Cysteine Protease

ZXH-4-130 TFA

Cat.No: T77920

Target: PROTACs

Ruxolitinib sulfate

Cat.No: T61988

Cat.No: T35989

Cat. No.	Product Name	Target	Signaling Pathways
T37751	Streptazolin
	Streptazolin is a fungal metabolite originally isolated from S. viridochromogenes. It increases NF-κB activity when used at concentrations ranging from 60 to 130 μg/ml, at least in part, via PI3K signaling. Streptazolin enhances TNF-α secretion induced by LPS and enhances IL-8 secretion when used alone or in combination with LPS in THP-1 Blue cells.

天然产物

Cat.No: T37751

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