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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12819 |
S130
|
Cysteine Protease | Proteases/Proteasome |
S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux. | |||
T77920 |
ZXH-4-130 TFA
|
PROTACs | PROTAC |
ZXH-4-130 TFA为高效、选择性CRBN降解剂,属于CRBN-VHL类(hetero-PROTAC)化合物。在MM1.S细胞中,10 nM ZXH-4-130 TFA可诱导约80%的CRBN降解。 | |||
T61988 |
Ruxolitinib sulfate
|
||
Ruxolitinib sulfate (INCB018424 sulfate) 是一种有效的JAK1/2抑制剂。Ruxolitinib sulfate 抑制JAK1/2的IC50为 3.3 nM/2.8 nM,高于 JAK3 130 倍。 | |||
T35989 |
CAY10565
|
||
S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10565 is a member of a new class of S-nitrosothiol species that act as NO donors under acidic conditions. It decomposes with a half-life of 130 minutes in 0.1 M phosphate buffer, pH 5.0,... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37751 |
Streptazolin
|
||
Streptazolin is a fungal metabolite originally isolated from S. viridochromogenes. It increases NF-κB activity when used at concentrations ranging from 60 to 130 μg/ml, at least in part, via PI3K signaling. Streptazolin enhances TNF-α secretion induced by LPS and enhances IL-8 secretion when used alone or in combination with LPS in THP-1 Blue cells. |