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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T6096 Pretomanid

(S)-PA 824,PA-824

Antibacterial; Antibiotic Microbiology/Virology
Pretomanid ((S)-PA 824) 是一种抗生素,可研究肺部多重耐药性结核病。它对结核病(MTB) 具有亚微摩尔作用活性。它对 MTB 泛敏感和抗 Rifampin 的临床分离株的 MIC 值为 0.015 至 0.25 μg/mL。
T26963 CBR-2092

TNP2092,CBR2092,TNP-2092,TNP 2092

CBR-2092 is a DNA-directed RNA polymerase and DNA topoisomerase inhibitor. CBR-2092 exhibited rifampin-like potency as an inhibitor of RNA polymerase, was an equipotent (balanced) inhibitor of DNA gyrase and DNA topoisomerase IV, and retained activity against a prevalent quinolone-resistant variant. Studies of mutant strains that exhibited reduced susceptibility to CBR-2092 further substantiated RNA polymerase as the primary cellular target of CBR-2092, with DNA gyrase and DNA topoisomerase IV b...
T37880 OPC-167832

OPC-167832 is a potent and orally active dprE1 Inhibitor with an IC50 of 0.258 μM. OPC-167832 has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis[1]. OPC-167832 exhibits very low MICs against laboratory strains of M. tuberculosis H37Rv (MIC: 0.0005 μg/ml) and Kurono (MIC: 0.0005 μg/ml) and strains with monoresistance to rifampin (RIF), isoniazid (INH), ethambutol (EMB), streptomycin (STR), and pyrazinamide (PZA) (MIC: 0.00024-0.001 ...

化合物

Pretomanid
Cat.No: T6096
Synonym: (S)-PA 824,PA-824
Target: Antibacterial, Antibiotic
CBR-2092
Cat.No: T26963
Synonym: TNP2092,CBR2092,TNP-2092,TNP 2092
Target:
OPC-167832
Cat.No: T37880
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T0681 Rifampicin

Rifamycin AMP,利福平,Rimactane,Rifampin

Influenza Virus; DNA/RNA Synthesis; Antibacterial; Antibiotic; Antifection Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
Rifampicin (Rifamycin AMP) 是广谱抗生素,可抵抗细菌病原体以及具有抗流感病毒活性。

天然产物

Rifampicin
Cat.No: T0681
Synonym: Rifamycin AMP,利福平,Rimactane,Rifampin
Target: Influenza Virus, DNA/RNA Synthesis, Antibacterial, Antibiotic, Antifection
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