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Cat. No. | Product Name | Target | Signaling Pathways |
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T0353 |
Osalmid
Oxaphenamide,4'-Hydroxysalicylanilide,羟苯水杨胺,柳胺酚 |
HBV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Osalmid (Oxaphenamide) 是一种利胆药物,通过靶向核糖核苷酸还原酶小亚基 M2 来抑制核糖核苷酸还原酶的活性,IC50值为8.23 μM。 | |||
T81251 |
rTRD01
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rTRD01为TDP-43配体,与TDP-43的RRM1和RRM2结构域结合(Kd=89 uM,TDP-43102-269)。该化合物能够削弱TDP-43与与疾病相关的c9orf72基因的六核苷酸RNA的交互作用,可作为神经退行性疾病研究的工具。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00937 |
RRM2 Protein, Human, Recombinant (His)
RRM2,RR2,Ribonucleotide Reductase... |
Human | HEK293 Cells |
Ribonucleoside-Diphosphate Reductase Subunit M2 (RRM2) belongs to the ribonucleoside diphosphate reductase small chain family. The reductase of RRM2 catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. RRM2 supplies the precursors essential for DNA synthesis. RRM2 catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Phosphorylation on Ser-20 relieves the in... | |||
TMPH-02084 |
SRRM2 Protein, Human, Recombinant (His & Myc)
|
Human | Baculovirus Insect Cells |
SRRM2 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus. |