Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38680 |
RJW100
|
Others | Others |
RJW100是一种化合物,作为肝受体同源体1(LRH-1, NR5A2)和类固醇生成因子-1(SF-1, NR5A1)的强效激动剂,分别展现出6.6和7.5的pEC50值。此外,RJW100能强力激活miR-200c(miRNA-200c, microRNA-200c)启动子。 | |||
T64363 |
(Iso)-RJW100
|
Others | Others |
(Iso)-RJW100 是一种有效的肝受体同源物 1 (LRH-1,NR5A2) 和类固醇生成因子-1 (SF-1,NR5A1) 激动剂,pEC50 分别为 6.4 和 7.2。 | |||
T61723 | SS-RJW100 | ||
SS-RJW100 is an enantiomer of RJW100, known as a racemic agonist that targets two nuclear receptors: liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). In vitro experiments reveal that SS-RJW100 promotes the recruitment of coregulator protein fragments and enhances the interaction with the transcriptional intermediary factor 2 (Tif2) coactivator specifically for LRH-1. Additionally, SS-RJW100 disrupts the allosteric activation networks of LRH-1, displaying suboptimal thermal sta... | |||
T73231 |
RR-RJW100
|
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RR-RJW100是RJW100的对映异构体之一,后者为核受体肝受体同源物1(LRH-1)和类固醇生成因子1(SF-1)的激动剂。相比于另一对映异构体SS-RJW100,RR-RJW100展现出更强的LRH-1激活能力。此化合物在调节代谢稳态方面具有潜力,因而在糖尿病、肝病以及炎症性肠病等疾病的研究中有所应用。 |