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8

抑制剂 & 化合物

21

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T75106	ARC186
	ARC 186 是一种核酸适配体，是高效的补体抑制剂，通过阻断转化酶催化的C5 激活发挥作用。
T74552	Non-PEGylated/naked ARC1905
	Non-PEGylated/naked ARC1905 是一种没有偶联PEG 的靶向补体因子5 (C5)的核酸适配体，抑制C5剪切为C5a 和C5b。Non-PEGylated/naked ARC1905 被用于研究与年龄相关的黄斑变性(AMD)。
T38693	TRC160334 TRC160334
	TRC160334 is a hydroxylase inhibitor of hypoxia-inducible factor (HIF). It is employed in research about ischemia/reperfusion injury.
T71044	TRC160334 sodium
	TRC160334 is a HIF hydroxylases inhibitor.
T75152	ARC19499
	ARC19499 是一种核酸适配体，与组织因子通路抑制剂(TFPI)特异性结合，阻断 TFPI 对factor Xa 和 TF/factor VIIa 复合物的抑制作用。ARC19499 纠正血友病A 和B 血浆中的凝血酶生成，并恢复凝血。
T78191	NH2-C6-ARC186	Complement System	Immunology/Inflammation
	NH2-C6-ARC186是带有NH2-C6接头的ARC186衍生物，可用于与其他肽或分子偶联。它作为一种适体，是一种高效的补体抑制剂，通过抑制转化酶催化的C5活化发挥作用。
T81743	mTORC1-IN-1	mTOR	PI3K/Akt/mTOR signaling
	mTORC1-IN-1（compound T1）为一种rapalog及选择性mTORC1抑制剂，调节细胞生长和代谢，与多种疾病如癌症相关。该化合物通过与FKBP12-FRB复合物结合（对接分数−11.6 kcal/mol）来靶向mTORC1。
T83744	Tiger17 TFA H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2
	Tiger17是一种环状肽，属于tigerinin-RC1和tigerinin-RC2的衍生物，这两种化合物是在螃蟹吃蛙（F. cancrivora）皮肤分泌物中发现的抗微生物肽。在5至20µg/ml的浓度范围内使用时，Tiger17能增加HaCaT角质形成细胞和人类皮肤成纤维细胞的增殖，并且在20µg/ml的浓度下增加HaCaT细胞的迁移。此外，Tiger17还能增加RAW 264.7巨噬细胞的招募及其TGF-β1和IL-6的分泌。在全层皮肤创伤的小鼠模型中，局部应用20µg/ml的Tiger17能加速伤口闭合和重新上皮化的速度。

化合物

Cat.No: T75106

Non-PEGylated/naked ARC1905

Cat.No: T74552

Cat.No: T38693

Synonym: TRC160334

TRC160334 sodium

Cat.No: T71044

Cat.No: T75152

Cat.No: T78191

Target: Complement System

Cat.No: T81743

Target: mTOR

Cat.No: T83744

Synonym: H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01090	CBX8 Protein, Human, Recombinant (His) Polycomb 3 homolog,hPc3,Pc3,Rectachrome 1,CBX8,Chro...	Human	E. coli
	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. CBX8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. Th...
TMPY-04333	LRRC15 Protein, Human, Recombinant (hFc) leucine rich repeat containing 15,LIB	Human	HEK293 Cells
	LRRC15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.5 kDa and the accession number is Q8TF66-1.
TMPY-01395	CTHRC1 Protein, Human, Recombinant (His) collagen triple helix repeat containing 1	Human	HEK293 Cells
	CTHRC1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.5 kDa and the accession number is Q96CG8-1.
TMPH-01123	CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc) Collagen triple helix repeat-containing protein 1,C...	Human	HEK293 Cells
	May act as a negative regulator of collagen matrix deposition. CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc) is expressed in HEK293 mammalian cells with C-hFC tag. The predicted molecular weight is 52 kDa and the accession number is Q96CG8.
TMPH-01904	HERC1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	HERC1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPK-01380	LRRC15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) LIB,EGM_11224,LRRC15	Cynomolgus,Rhesus	HEK293 Cells
	The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro. LRRC15 Prote...
TMPH-02593	CTHRC1 Protein, Mouse, Recombinant (His & SUMO) Collagen triple helix repeat-containing protein 1,C...	Mouse	E. coli
	May act as a negative regulator of collagen matrix deposition.
TMPY-06910	LRRC15 Protein, Cynomolgus, Recombinant (His) leucine rich repeat containing 15	Cynomolgus	HEK293 Cells
	LRRC15 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.28 kDa and the accession number is G7NYR2.
TMPY-04288	CTHRC1 Protein, Rat, Recombinant (His) collagen triple helix repeat containing 1	Rat	HEK293 Cells
	CTHRC1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.8 kDa and the accession number is NP_001258229.1.
TMPY-06826	CTHRC1 Protein, Human, Recombinant (His & Avi), Biotinylated collagen triple helix repeat containing 1	Human	HEK293 Cells
	CTHRC1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 26.33 kDa and the accession number is NP_612464.1.
TMPJ-00338	LRRC15 Protein, Human, Recombinant (His & Avi), Biotinylated Leucine-rich repeat-containing protein 15,LIB,LR	Human	HEK293 Cells
	The type I transmembrane protein 15-leucine-rich repeat containing membrane protein (LRRC15) is a member of the LRR superfamily. The LRR family is a structural module for protein-protein and protein-matrix interactions used for molecular recognition process such as cell adhesion, signal transduction, DNA repair, and RNA processing. The LRRC15 is also a transmembrane protein demonstrated to play important roles in cancer. LRRC15 expression was notably increased 4.6-fold in cariesdiseased pulpal t...
TMPH-02592	CTHRC1 Protein, Mouse, Recombinant (aa 33-245, His) Collagen triple helix repeat-containing protein 1,C...	Mouse	HEK293 Cells
	May act as a negative regulator of collagen matrix deposition.
TMPY-06795	CTHRC1 Protein, Mouse, Recombinant (His) 1110014B07Rik,collagen t...	Mouse	HEK293 Cells
	CTHRC1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.53 kDa and the accession number is Q9D1D6.
TMPH-01632	MRC1 Protein, Human, Recombinant (His)	Human	E. coli
	Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.; (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.; (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.; (Microbial infection) Interacts with Hepatitis B virus envelope protein. MRC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 69.9...
TMPY-02714	PRC1 Protein, Human, Recombinant (His) ASE1,protein regulator of cytokinesis 1	Human	Baculovirus Insect Cells
	PRC1 (protein regulator of cytokinesis 1) is a key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. It is essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. PRC1 is required for KIF14 localization to the central spindle and midbody. It is also required to recruit PLK1 to the spindle. PRC1 stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. It is a homodi...
TMPY-06148	LRRC15 Protein, Human, Recombinant (His) leucine rich repeat containing 15,LIB	Human	HEK293 Cells
	LRRC15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.2 kDa and the accession number is Q8TF66-1.
TMPK-01070	LRRC15 Protein, Mouse, Recombinant (His) LIB,LRRC15	Mouse	HEK293 Cells
	The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro. LRRC15 Prote...
TMPK-00338	LRRC15 Protein, Human, Recombinant (His & Avi) LRRC15,LIB	Human	CHO Cells
	The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro. LRRC15 Prote...
TMPK-01309	LRRC15 Protein, Canine, Recombinant (His) LIB,LRRC15	Canine	HEK293 Cells
	The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro. LRRC15 Prote...
TMPY-06919	LRRC15 Protein, Mouse, Recombinant (His & Avi), Biotinylated LIB,leucine rich repeat containing 15,5430427N1...	Mouse	HEK293 Cells
	LRRC15 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 60.74 kDa and the accession number is NP_083249.1.
TMPY-06775	CTHRC1 Protein, Human, Recombinant (hFc) collagen triple helix repeat containing 1	Human	HEK293 Cells
	CTHRC1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.8 kDa and the accession number is NP_612464.1.

重组蛋白

CBX8 Protein, Human, Recombinant (His)

Cat.No: TMPH-01090

Species: Human

Expression System: E. coli

LRRC15 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04333

Species: Human

Expression System: HEK293 Cells

CTHRC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01395

Species: Human

Expression System: HEK293 Cells

CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc)

Cat.No: TMPH-01123

Species: Human

Expression System: HEK293 Cells

HERC1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01904

Species: Human

Expression System: E. coli

LRRC15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

Cat.No: TMPK-01380

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

CTHRC1 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02593

Species: Mouse

Expression System: E. coli

LRRC15 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-06910

Species: Cynomolgus

Expression System: HEK293 Cells

CTHRC1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04288

Species: Rat

Expression System: HEK293 Cells

CTHRC1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06826

Species: Human

Expression System: HEK293 Cells

LRRC15 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00338

Species: Human

Expression System: HEK293 Cells

CTHRC1 Protein, Mouse, Recombinant (aa 33-245, His)

Cat.No: TMPH-02592

Species: Mouse

Expression System: HEK293 Cells

CTHRC1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06795

Species: Mouse

Expression System: HEK293 Cells

MRC1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01632

Species: Human

Expression System: E. coli

PRC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02714

Species: Human

Expression System: Baculovirus Insect Cells

LRRC15 Protein, Human, Recombinant (His)

Cat.No: TMPY-06148

Species: Human

Expression System: HEK293 Cells

LRRC15 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01070

Species: Mouse

Expression System: HEK293 Cells

LRRC15 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00338

Species: Human

Expression System: CHO Cells

LRRC15 Protein, Canine, Recombinant (His)

Cat.No: TMPK-01309

Species: Canine

Expression System: HEK293 Cells

LRRC15 Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06919

Species: Mouse

Expression System: HEK293 Cells

CTHRC1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-06775

Species: Human

Expression System: HEK293 Cells

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