Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-01014 |
ULBP-6 Protein, Human, Recombinant (aa 26-218, hFc)
RAET1L,ULBP6 |
Human | HEK293 Cells |
ULBP6/RAET1L (UL16-binding protein, also known as retinoic acid early transcript), is expressed as a full-lengthtranscript in cells and encodes a protein that is a ligand for bothNKG2D and the UL16 protein of HCMV. | |||
TMPY-00190 |
ULBP-6 Protein, Human, Recombinant (hFc)
retinoic acid early transcript 1L,RAET... |
Human | HEK293 Cells |
ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript. ULBP6 had a more restricted expression profile in cell lines and primary human tissues than other NKG2D ligands, but expression was detected in several human papillomavirus-positive cervical carcinoma cell lines and was inducible on infection with human CMV. Expression of ULBP6 on target cells induced a significant increase in NK-cell killing. ULBP-6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cel... | |||
TMPY-00575 |
ULBP-6 Protein, Human, Recombinant (His)
RAET1L,retinoic acid early transcript ... |
Human | HEK293 Cells |
ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript. ULBP6 had a more restricted expression profile in cell lines and primary human tissues than other NKG2D ligands, but expression was detected in several human papillomavirus-positive cervical carcinoma cell lines and was inducible on infection with human CMV. Expression of ULBP6 on target cells induced a significant increase in NK-cell killing. ULBP-6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cel... | |||
TMPK-00137 |
ULBP-2 Protein, Human, Recombinant (His & Avi), Biotinylated
ALCAN-α,NKG2DL2,ULBP2,ALCAN-alpha,ULBP-2/5/6,N2DL2,RAET<... |
Human | HEK293 Cells |
ULBP2 expression was however linked to expression of mature CD57() NK cells. In particular, expression of ULBP2 was strongest on those NK cells that had evidence of recent activation and proliferation. We suggest that ULBP2 could be used to identify recently activated "mature" NK cells. | |||
TMPK-00136 |
ULBP-2 Protein, Human, Recombinant (His & Avi)
ALCAN-α,RAET1L,NKG2D ligand 2,ALCAN-alpha,... |
Human | HEK293 Cells |
ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway, mediating natural killer cell cytotoxicity. |