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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T11181	EMD638683 R-Form	SGK	Metabolism
	EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.
T10472	Bay 65-1942 (R form) Bay 65-1942 R form	Others	Others
	Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.
T38041	(R)-3-hydroxy Myristic Acid
	Lipopolysaccharides (LPS) are components of the cell walls of Gram-negative bacteria. LPS is composed of polysaccharides and lipid A, where lipid A is a phosphoglycolipid containing acyl chains composed of 10 to 16 carbons. The lipid A component of LPS is detected by Toll-like receptor 4 of mammalian leukocytes and, thus, is a key determinant in immune response. (R)-3-Hydroxymyristic Acid is a form of the 14:0 lipid myristic acid that is found in the lipid A component of some Gram-negative bacte...
T12656	(Rac)-Apremilast D5 (Rac)-CC-10004 D5	Others	Others
	(Rac)-Apremilast D5 is a deuterium-labeled version of the enantiomer (R)-Apremilast, also known as (R)-CC-10004, which itself is one specific form of Apremilast.
T37227	(±)8(9)-DiHET
	Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.
T35458	(R)-nitro-Blebbistatin
	(R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin , which is the inactive form of (-)-blebbistatin . Prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a nitro group stabilizes the molecule to circumvent its degradation by prolonged blue light exposure. (R)-nitro-Blebbistatin has the same stereoche...
T63089	(R)-IL-17 modulator 4
	(R)-IL-17 modulator 4 是 IL-17 modulator 4 的 R 构型形式，是 IL-17 modulator 1 的前药。其中 IL-IL-17 modulator 1 是一种高效的、口服具有活力的 IL-17 调节剂。
T38025	Cyclohexanoyl Coenzyme A
	Cyclohexanoyl coenzyme A (CHCoA) is an acyl CoA that contains a cyclohexane group. It is the activated form of cyclohexane carboxylic acid (CHC) in R. palustris. CHC is converted to CHCoA by a succinyl-CoA CHC CoA transferase, and CHCoA is then degraded by a dehydrogenase. CHCoA is converted to hippuric acid in submitochondrial fractions isolated from guinea pig liver.
T35946	17(R)-Resolvin D1 Aspirin-triggered Resolvin D1,17(R)-Resolvin D1
	Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the ear...
T32705	Levomefolate magnesium L-Methylfolate magnesium
	Levomefolate magnesium is the magnesium salt of the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma. It is transported across th
T18667	(S,R,S)-AHPC-C5-COOH VH032-C5-COOH	Others	Others
	(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases[1].
T37679	3-hydroxy Palmitic Acid
	3-hydroxy Palmitic acid is a form of the 16:0 lipid palmitic acid . The lipid A part of lipopolysaccharides contain various 3-hydroxy fatty acids, making oxylipins such as 3-hydroxy palmitic acid useful as chemical markers of endotoxins. In R. solanacearum, 3-hydroxy palmitic acid is converted by an S-adenosyl methionine-dependent methyltransferase to 3-hydroxy palmitic acid methyl ester, which acts as a quorum sensing signal molecule for post-transcriptional modulation of genes involved in viru...
T35659	3'-Dephosphocoenzyme A
	3'-Dephosphocoenzyme A is an intermediate in the biosynthesis of coenzyme A from pantothenic acid .1 It is phosphorylated by CoA synthase in humans to form CoA. 3'-Dephosphocoenzyme A can be used as a transcription initiator in the synthesis of CoA-RNA by in vitro transcription.2,3 References1. Leonardi, R., Zhang, Y.M., Rock, C.O., et al. Coenzyme A: Back in action. Prog. Lipid Res. 44(2-3), 125-153 (2005).2. Huang, F. Efficient incorporation of CoA, NAD and FAD into RNA by in vitro transcripti...
T38076	ThioGlo1 ThioGlo1
	ThioGlo1 is a thiol-reactive fluorescent probe.1,2,3Upon reaction with a thiol group, a fluorescent adduct is formed that displays excitation/emission maxima of 384/513 nm, respectively.2,3It also reacts with sulfite to form a fluorescent adduct with similar spectral characteristics, and interference from sulfite during thiol determination must be accounted for using secondary methods. ThioGlo1 has been used to monitor the oxidative stability of beer. 1.Yang, J.-R., and Langmuir, M.E.Synthesis a...
T35742	IKD-8344
	IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.2,3 It is active against T. spiralis in vit...
T36660	Olsalazine-13C6 Olsalazine-13C6
	Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50= 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of ...
T38297	Ribavirin-13C5 Ribavirin-13C5
	Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro...

化合物

EMD638683 R-Form

Cat.No: T11181

Target: SGK

Bay 65-1942 (R form)

Cat.No: T10472

Synonym: Bay 65-1942 R form

Target: Others

(R)-3-hydroxy Myristic Acid

Cat.No: T38041

(Rac)-Apremilast D5

Cat.No: T12656

Synonym: (Rac)-CC-10004 D5

Target: Others

Cat.No: T37227

(R)-nitro-Blebbistatin

Cat.No: T35458

(R)-IL-17 modulator 4

Cat.No: T63089

Cyclohexanoyl Coenzyme A

Cat.No: T38025

17(R)-Resolvin D1

Cat.No: T35946

Synonym: Aspirin-triggered Resolvin D1,17(R)-Resolvin D1

Levomefolate magnesium

Cat.No: T32705

Synonym: L-Methylfolate magnesium

(S,R,S)-AHPC-C5-COOH

Cat.No: T18667

Synonym: VH032-C5-COOH

Target: Others

3-hydroxy Palmitic Acid

Cat.No: T37679

3'-Dephosphocoenzyme A

Cat.No: T35659

Cat.No: T38076

Synonym: ThioGlo1

Cat.No: T35742

Olsalazine-13C6

Cat.No: T36660

Synonym: Olsalazine-13C6

Cat.No: T38297

Synonym: Ribavirin-13C5

Cat. No.	Product Name	Target	Signaling Pathways
T40576	(S)-Salsolidine
	(S)-Salsolidine, a chemical compound, functions as a weak inhibitor of monoamine oxidase (MAO), exhibiting an inhibition constant (K i ) of 63 μM. R enantiomer demonstrating a greater efficacy than (S)-Salsolidine, boasting a K i value of 26 μM compared to the S form.

天然产物

(S)-Salsolidine

Cat.No: T40576

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