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9

抑制剂 & 化合物

1

天然产物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T37158	8(S)-HETE
	8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.
T83926	S-Geranylgeranyl-L-glutathione GGG
	S-Geranylgeranyl-L-glutathione是孤儿G蛋白偶联受体（GPCR）P2RY8的配体。该化合物在100 nM浓度下，选择性地诱导P2RY8而非鞘氨醇-1-磷酸受体2（S1P2）、GPR55、半胱氨酸白三烯受体1（CysLT1 receptor）以及CysLT2 receptor的内吞作用。在10 nM浓度下，S-Geranylgeranyl-L-glutathione抑制了表达P2RY8的WEHI-231 B细胞淋巴瘤细胞和分离的人扁桃体生发中心B细胞由趋化因子（C-X-C motif）配体12（CXCL12）诱导的迁移。
T36802	Bisubstrate Inhibitor 78
	Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50= 1.41 μM).1It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinamide . Bisubstrate inhibitor 78 is selective for NNMT over histone-lysine N-methytransferase NSD2 and protein arginine methyltransferase 1 (PRMT1; IC50s = >50 μM for both). It reduces levels of 1-methylnicotinamide in, and inhibits proliferation of, HSC-2 oral cancer cells when us...
T36434	Sordarin sodium
	Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa.[1] It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC50 = 0.1 μM). Sordarin inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC50s = 0.01, 0.2, and 0.06 μg/ml, respectively) but not in rabbit reticulocytes (IC50 = >100 μg/ml).[1] [2] It...
T35817	Photoswitchable PAD Inhibitor (technical grade)
	Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity.1 Without photoactivation, it is a weak inhibitor of PAD2 (IC50 = >100 μM) and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro (kinact/KIs = 2,300, 600, 1,000, and 10,510 M-1min-1 for PAD1-4, respectively) and does not inhibit histone H3 citrullination in HEK29...
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...
T36779	NG 25 (hydrochloride hydrate)
	NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38α (IC50s = 56.4, 82.3, and 102 nM, respectively). NG 25 (100 nM) prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectiv...
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9,...
T36717	RWJ-56110 dihydrochloride
	RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 . RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell ap...

化合物

Cat.No: T37158

S-Geranylgeranyl-L-glutathione

Cat.No: T83926

Synonym: GGG

Bisubstrate Inhibitor 78

Cat.No: T36802

Sordarin sodium

Cat.No: T36434

Photoswitchable PAD Inhibitor (technical grade)

Cat.No: T35817

Cat.No: T36629

NG 25 (hydrochloride hydrate)

Cat.No: T36779

Cat.No: T37861

RWJ-56110 dihydrochloride

Cat.No: T36717

Cat. No.	Product Name	Target	Signaling Pathways
T38330	Collinin
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...

天然产物

Cat.No: T38330

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00990	S100B Protein, Mouse, Recombinant (His) S-100 protein subunit be...	Mouse	E. coli
	S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal flui...
TMPK-01369	S100B Protein, Canine, Recombinant (hFc) S100 calcium-binding,S100	Canine	HEK293 Cells
	S100B, a calcium-binding protein of the EF-hand type exerts both intracellular and extracellular functions.The intracellular, and extracellular, roles of S100B are attractive therapeutic targets for the treatment of both cardiac and vascular disease.
TMPY-00997	S100A1 Protein, Human, Recombinant S100-α,S100A,S<...	Human	E. coli
	S100A1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 10.5 kDa and the accession number is A0A0S2Z4H2.
TMPY-02531	S100B Protein, Human, Recombinant (His) S100β,S100-B,S<...	Human	E. coli
	S100B Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12 kDa and the accession number is A0A0S2Z4C5.
TMPY-02532	S100A1 Protein, Mouse, Recombinant (His) AI266795,S100a,S100 calc...	Mouse	E. coli
	S100A1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.5 kDa and the accession number is P56565.
TMPY-00913	S100B Protein, Human, Recombinant (hFc) NEF,S100 calcium binding protein ...	Human	HEK293 Cells
	S100B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.2 kDa and the accession number is A0A0S2Z4C5.
TMPY-00909	S100A1 Protein, Human, Recombinant (hFc) S100 calcium binding protein A1,<...	Human	HEK293 Cells
	S100A1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.1 kDa and the accession number is A0A0S2Z4H2.
TMPJ-00991	S100A8 Protein, Rat, Recombinant (His) Leukocyte L1 complex light chain,Migration inhibitory factor...	Rat	E. coli
	Protein S100-A8(Mrp8) contains 2 EF-hand domains and belongs to the S-100 family. Mrp8 binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. It may function in the inhi...
TMPY-01879	S100A14 Protein, Human, Recombinant (His) S100 calcium binding protein A14,...	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from theneural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of in...
TMPY-01466	S100A12 Protein, Human, Recombinant MRP6,MRP-6,S100A12,S100 ...	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of i...

重组蛋白

S100B Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00990

Species: Mouse

Expression System: E. coli

S100B Protein, Canine, Recombinant (hFc)

Cat.No: TMPK-01369

Species: Canine

Expression System: HEK293 Cells

S100A1 Protein, Human, Recombinant

Cat.No: TMPY-00997

Species: Human

Expression System: E. coli

S100B Protein, Human, Recombinant (His)

Cat.No: TMPY-02531

Species: Human

Expression System: E. coli

S100A1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02532

Species: Mouse

Expression System: E. coli

S100B Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00913

Species: Human

Expression System: HEK293 Cells

S100A1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00909

Species: Human

Expression System: HEK293 Cells

S100A8 Protein, Rat, Recombinant (His)

Cat.No: TMPJ-00991

Species: Rat

Expression System: E. coli

S100A14 Protein, Human, Recombinant (His)

Cat.No: TMPY-01879

Species: Human

Expression System: E. coli

S100A12 Protein, Human, Recombinant

Cat.No: TMPY-01466

Species: Human

Expression System: E. coli

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