Cat. No. | Product Name | Target | Signaling Pathways |
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T65396 |
Piperazine 2HCl
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Piperazine (2HCl) is gamma-aminobutyric acid (GABA) agonists and its major effects appear to be on the central nervous system. Piperazine was the anthelmintic with the greatest number of reports of toxicoses and suspected toxicoses in cats. Piperazine neurotoxicity in cats and dogs usually was manifested by muscle tremors, ataxia, and/or behavioral disturbances within 24 hours after estimated daily dose(s) between 20 and 110 mg/kg[1]. For di-substituted derivatives, ciprofloxacin was selected an... | |||
T1110 |
Meclizine dihydrochloride
Meclozine dihydrochloride,NSC28728,Meclizine 2HCl,盐酸美克洛嗪 |
Apoptosis; Histamine Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Meclizine dihydrochloride (NSC28728) 是一种组胺 H1 拮抗剂,用于治疗妊娠期间的晕动病、眩晕和恶心以及放射病。它是小鼠组成型雄甾烷受体激动剂,是人 CAR 的反向激动剂。它可透过血脑屏障,可用于多聚谷氨酰胺毒性障碍方面的研究。 |