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Cat. No.	Product Name	Target	Signaling Pathways
T11975	PROTAC Mcl1 degrader-1	BCL	Apoptosis
	PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.
T10485	PROTAC Bcl2 degrader-1	BCL	Apoptosis
	PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).
T78837	CP-07	CDK	Cell Cycle/Checkpoint
	CP-07为高效的PROTAC CDK9选择性降解剂（DC50：43 nM），能显著抑制22RV1细胞增殖（IC50：62 nM）及集落形成，其作用机制为通过下调Mcl-1与c-Myc。此外，CP-07有效抑制22RV1异种移植肿瘤的生长，有望成为研究前列腺癌的重要化合物。