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Cat. No.	Product Name	Target	Signaling Pathways
T7701	Boc-NH-PEG3 PROTAC Linker 10,2-[2-(2-T-BOC-氨基乙氧基)乙氧基]乙醇	Others; PROTAC Linker	Others; PROTAC
	Boc-NH-PEG3 (PROTAC Linker 10) 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 的合成分子。
T14413	Azido-PEG10-alcohol 叠氮-十聚乙二醇	Others; PROTAC Linker	Others; PROTAC
	Azido-PEG10-alcohol 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T17694	Br-C10-methyl ester 11-溴代十一烷酸甲酯	Others; PROTAC Linker	Others; PROTAC
	Br-C10-methyl ester 是一种属于 alkyl/ether 类的 PROTAC linker，可用于一系列 PROTAC 分子的合成。PROTAC 分子含有两个通过 linker 连接的不同配体，一种是 VHL 配体部分，另一种是靶蛋白配体。
T17881	(S,R,S)-AHPC-C10-NH2 VH032-C10-NH2	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) 包含基于 (S,R,S)-AHPC 的VHL 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物 (E3 ligase ligand-linker conjugate)。用于 BET 的靶向 PROTAC 的合成。
T18661	(S,R,S)-AHPC-C10-NH2 dihydrochloride VH032-C10-NH2 dihydrochloride,VH032-linker 10,(S,R,S)-AHPC-C10-NH2二盐酸盐,VH032 amide-alkylC10-amine	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-linker 10) 包含基于 (S,R,S)-AHPC 的VHL 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物，用于合成 BET 的靶向 PROTAC。
T18680	SD-36	Others; PROTACs	Others; PROTAC
	SD-36, a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), exhibits high specificity for STAT3 over other STAT members. It effectively targets both wild-type and mutated STAT3 proteins in cells, inhibiting their transcriptional activity (IC50=10 nM). The compound, consisting of the STAT3 inhibitor SI-109, a linker, and a CRBN ligand Lenalidomide analog for E3 ubiquitin ligase[1], demonstrates significant anti-tumor effects and achieves complete, long-lasting tumor regression in mouse mod...
T15120	Diethyl 10-bromodecylphosphonate	Others	Others
	Diethyl 10-bromodecylphosphonate is an alkyl-based PROTAC linker utilized for the synthesis of PROTACs[1].
T17901	cIAP1 Ligand-Linker Conjugates 10 E3 ligase Ligand-Linker Conjugates 47	Others	Others
	cIAP1 Ligand-Linker Conjugates 10 comprise of an IAP ligand and a PROTAC linker, which facilitates the design of SNIPERs. These conjugates incorporate an IAP ligand that interacts with the E3 ubiquitin ligase, and a PROTAC linker. SNIPERs can be developed using cIAP1 Ligand-Linker Conjugates 10.
T13999	(10-BRomodecyl)phosphonic acid	Others	Others
	(10-BRomodecyl)phosphonic acid is an alkyl chain-derived PROTAC linker suitable for PROTAC synthesis [1].
T18515	Palbociclib-propargyl PROTAC CDK6 ligand 1	Others	Others
	Palbociclib-propargyl, a PROTAC ligand targeting the protein CDK6, connects to the CRBN ligand through a PEG linker to form PROTAC CP-10. CP-10 exhibits a potent DC50 value of 2.1 nM against CDK6[1].
T14000	[10-(Diethoxy-phosphoryl)-decyl]-phosphonic acid	Others	Others
	The compound [10-(diethoxy-phosphoryl)-decyl]-phosphonic acid is a suitable alkyl chain-based PROTAC linker for the synthesis of PROTACs [1].
T16583	Propargyl-PEG1-acid	Others	Others
	Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and induces the degradation of CSK, LYN, and LAT2[1].
T17904	Pomalidomide-PEG1-C2-N3 E3 ligase Ligand-Linker Conjugates 50,Cereblon Ligand-Linker Conjugates 13	Others	Others
	Pomalidomide-PEG1-C2-N3 is a compound that has been synthesized as a conjugate of an E3 ligase ligand-linker. This compound incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, which are commonly used in PROTAC technology. Utilizing Pomalidomide-PEG1-C2-N3, it is possible to design a selective CDK6 PROTAC degrader known as CP-10. CP-10 effectively induces the degradation of CDK6, displaying a DC50 value of 2.1 nM[1].
T18682	SJFδ	Others	Others
	SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].
T15834	m-PEG10-alcohol Decaethylene glycol monomethyl ether	Others	Others
	m-PEG10-alcohol, also known as Decaethylene glycol monomethyl ether, is a non-cleavable 10 unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, m-PEG10-alcohol serves as a PEG-based PROTAC linker, enabling its application in the synthesis of PROTACs[1].
T71919	Boc-10-Aminodecanoic acid
	Boc-10-Aminodecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-10-Aminodecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
T18601	Desmethyl-QCA276 PROTAC BRD4-binding moiety 4	Others	Others
	Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1].
T41146	ND1-YL2 ND1-YL2
	ND1-YL2 is a peptide-based PROTAC®Degrader of steroid receptor co-activator 1 (SRC-1; also known as nuclear receptor coactivator 1, NCOA1). ND1-YL2 is composed of a stapled peptide that binds SRC-1 (YL2) joined by a linker to a tetrapeptide that binds UBR box domains. Upon ternary complex formation, SRC-1 is polyubiquitinated and subsequently degraded via the N-degron pathway. This Degrader induces dose-dependent degradation of SRC-1 in the MDA-MB-231 triple negative breast cancer cell line (DC5...
T83856	AP-1
	AP-1是一种微型化的蛋白质水解靶向嵌合体（PROTAC），由吲哚美辛（±）连接的间变性淋巴瘤激酶（ALK）配体和E3泛素连接酶配体通过超短连接器相连。在10至300 nM浓度范围内使用时，AP-1能高效降解Karpas-299细胞中高表达的ALK融合蛋白NPM-ALK，此效应可被蛋白酶体抑制剂MG-132阻断。它还能降解在SN-N-SH和NCI H3122细胞中表达的ALK融合蛋白EML4-ALK及含有苯丙氨酸至亮氨酸替换突变（ALKF1174L）的ALK。AP-1对依赖ALK的Karpas-299细胞具有细胞毒性（IC50 = 0.1265 nM），但对非ALK依赖的THP-1细胞无细胞毒性（IC50 = 2,704 nM）。在给药剂量为25, 50, 和100 mg/kg时，能减小NCI H3122小鼠移植瘤模型中的肿瘤体积。

化合物

Cat.No: T7701

Synonym: PROTAC Linker 10,2-[2-(2-T-BOC-氨基乙氧基)乙氧基]乙醇

Target: Others, PROTAC Linker

Azido-PEG10-alcohol

Cat.No: T14413

Synonym: 叠氮-十聚乙二醇

Target: Others, PROTAC Linker

Br-C10-methyl ester

Cat.No: T17694

Synonym: 11-溴代十一烷酸甲酯

Target: Others, PROTAC Linker

(S,R,S)-AHPC-C10-NH2

Cat.No: T17881

Synonym: VH032-C10-NH2

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-C10-NH2 dihydrochloride

Cat.No: T18661

Synonym: VH032-C10-NH2 dihydrochloride,VH032-linker 10,(S,R,S)-AHPC-C10-NH2二盐酸盐,VH032 amide-alkylC10-amine

Target: Others, Ligand for E3 Ligase

Cat.No: T18680

Target: Others, PROTACs

Diethyl 10-bromodecylphosphonate

Cat.No: T15120

Target: Others

cIAP1 Ligand-Linker Conjugates 10

Cat.No: T17901

Synonym: E3 ligase Ligand-Linker Conjugates 47

Target: Others

(10-BRomodecyl)phosphonic acid

Cat.No: T13999

Target: Others

Palbociclib-propargyl

Cat.No: T18515

Synonym: PROTAC CDK6 ligand 1

Target: Others

[10-(Diethoxy-phosphoryl)-decyl]-phosphonic acid

Cat.No: T14000

Target: Others

Propargyl-PEG1-acid

Cat.No: T16583

Target: Others

Pomalidomide-PEG1-C2-N3

Cat.No: T17904

Synonym: E3 ligase Ligand-Linker Conjugates 50,Cereblon Ligand-Linker Conjugates 13

Target: Others

Cat.No: T18682

Target: Others

m-PEG10-alcohol

Cat.No: T15834

Synonym: Decaethylene glycol monomethyl ether

Target: Others

Boc-10-Aminodecanoic acid

Cat.No: T71919

Desmethyl-QCA276

Cat.No: T18601

Synonym: PROTAC BRD4-binding moiety 4

Target: Others

Cat.No: T41146

Synonym: ND1-YL2

Cat.No: T83856

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