Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13842 |
PROTAC IRAK4 degrader-1
|
Others | Others |
PROTAC IRAK4 degrader-1 is a degrader of PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4). | |||
T7755 |
Thalidomide 4-fluoride
E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮 |
IRAK; Ligand for E3 Ligase | Immunology/Inflammation; NF-κB; PROTAC |
Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接,得到 PROTAC IRAK4 degrader-1。 | |||
T81378 |
PROTAC IRAK4 ligand-3
|
PROTACs | PROTAC |
PROTACIRAK4 ligand-3 为 PROTACIRAK4 degrader-7 配体,适用于癌症研究领域。 | |||
T79097 |
PROTAC IRAK4 degrader-8
|
IRAK | Immunology/Inflammation; NF-κB |
PROTAC-IRAK4分解剂-8(化合物2)是针对IRAK4设计的PROTAC,表现出15.5 nM的IC50值。 | |||
T74411 |
PROTAC IRAK4 degrader-7
|
||
PROTACIRAK4 degrader-7 (Compound I-417) 是一种具有口服活性的 PROTACIRAK4降解剂,具有抗肿瘤效果。 | |||
T39903 |
PROTAC IRAK4 degrader-6
PROTAC IRAK4 degrader-6 |
||
PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4). | |||
T39901 |
PROTAC IRAK4 degrader-4
PROTAC IRAK4 degrader-4 |
||
PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4). | |||
T17388 | AM-Imidazole-PA-Boc | Others | Others |
AM-Imidazole-PA-Boc is an alkyl chain-derived PROTAC linker utilized for the synthesis of PROTAC IRAK4 degrader-1[1]. | |||
T74062 | PROTAC IRAK4 degrader-2 | ||
PROTACIRAK4 degrader-2 (Compound 9) 是一种 PROTACIRAK4降解剂,在外周血单个核细胞 (PBMC) 中,降解 IRAK4,DC50为 151 nM。PROTACIRAK4 Degrader-2 在 PBMC 细胞中诱导 IRAK4蛋白水平降低,DC50为 36 nM。PROTACIRAK4 degrader-2 还抑制 PBMC 中多种细胞因子释放。 |