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Cat. No. Product Name Target Signaling Pathways
T36242 PROTAC BRD4 Degrader-5

PROTAC BRD4 Degrader-5

PROTACs PROTAC
PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].
T31221L dBRD9 HCl

dBRD9 HCl(2170679-45-3 Free base)

Epigenetic Reader Domain Chromatin/Epigenetic
dBRD9 HCl 是一种PROTAC,包含cereblon E3连接酶配体与BRD9抑制剂BI 7273。dBRD9 HCl 是有效和选择性的BRD9降解剂,在MOLM-13细胞中IC50的为56.6nM。dBRD9 HCl 在浓度高达5μM 时不会降解BRD4BRD7。dBRD9 HCl 在人AML 细胞系中显示出抗增殖作用。
T39985 (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2

(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2

(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthetic E3 ligase ligand-linker conjugate comprised of a VHL ligand and a linker. It is utilized in PROTAC BRD4 Degrader-5 and PROTAC BRD4 Degrader-5-CO-PEG3-N3.
T18603 PROTAC BRD4 degrader for PAC-1

Others Others
PROTAC BRD4 degrader for PAC-1 (compound 5) is a chimeric BET degrader GNE-987 conjugated with a disulfide-containing linker[1]. This PROTAC-linker conjugate specifically targets and degrades BRD4, enabling selective proteolysis of PAC-1.
T17297 ZXH-3-26

Epigenetic Reader Domain; PROTACs Chromatin/Epigenetic; PROTAC
ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
T36628 PROTAC BRD4 Degrader-8

PROTAC BRD4 Degrader-8

PROTACs PROTAC
PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1]. PROTAC BRD4 Degrader-8 (compound 8; 6 days) inhibits the proliferation of PC3 prostate cancer cells, with an IC50 of 28 nM[1].PROTAC BRD4 Degrader-8 (4 h) suppresses MYC gene transcript in MV4-11 AML cells, with an IC50 of 11 nM[1].PROTAC BRD4 Degrader-8 (4 h) potently degra...

化合物

PROTAC BRD4 Degrader-5
Cat.No: T36242
Synonym: PROTAC BRD4 Degrader-5
Target: PROTACs
dBRD9 HCl
Cat.No: T31221L
Synonym: dBRD9 HCl(2170679-45-3 Free base)
Target: Epigenetic Reader Domain
(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2
Cat.No: T39985
Synonym: (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2
Target:
PROTAC BRD4 degrader for PAC-1
Cat.No: T18603
Synonym:
Target: Others
ZXH-3-26
Cat.No: T17297
Synonym:
Target: Epigenetic Reader Domain, PROTACs
PROTAC BRD4 Degrader-8
Cat.No: T36628
Synonym: PROTAC BRD4 Degrader-8
Target: PROTACs
TargetMol Loading
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