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Cat. No. Product Name Target Signaling Pathways
T12559 PROTAC BET degrader-2

Others Others
PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).
T5435 ARV-771

Epigenetic Reader Domain Chromatin/Epigenetic
ARV-771 是基于 PROTAC 技术的有效 BET 降解剂,对 BRD2(1)、BRD2(2)、BRD3(1)、BRD3(2)、BRD4 (1) 和 BRD4(2)的 Kd 分别为 34、4.7、8.3、7.6、9.6 和 7.6 nM。
T7752 (S,R,S)-AHPC-Me

VHL ligand 2,E3 ligase Ligand 1A

Ligand for E3 Ligase PROTAC
(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) 是基于 (S,R,S)-AHPC 的的 VHL 配体,可用于募集 von Hippel-Lindau (VHL) 蛋白。它可有效降解去势抵抗性前列腺癌细胞中的 BET 蛋白,DC50<1 nM。它可用于合成 ARV-771。
T13671L (S,R,S)-AHPC-Me dihydrochloride

VHL ligand 2 dihydrochloride,E3 ligase Ligand 1 dihydrochloride,(S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)

Others Others
(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound utilized in the synthesis of ARV-771. ARV-771, a BET PROTAC degrader relying on von Hippel-Landau (VHL) E3 ligase, demonstrates potent degradation of BET protein in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound serves as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, that facilitates the recruitment of von Hippel-Lindau (VHL) prote...

化合物

PROTAC BET degrader-2
Cat.No: T12559
Synonym:
Target: Others
ARV-771
Cat.No: T5435
Synonym:
Target: Epigenetic Reader Domain
(S,R,S)-AHPC-Me
Cat.No: T7752
Synonym: VHL ligand 2,E3 ligase Ligand 1A
Target: Ligand for E3 Ligase
(S,R,S)-AHPC-Me dihydrochloride
Cat.No: T13671L
Synonym: VHL ligand 2 dihydrochloride,E3 ligase Ligand 1 dihydrochloride,(S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)
Target: Others
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