Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16670 |
PS210
|
PDK | PI3K/Akt/mTOR signaling |
PS210 是针对 PDK1的 PIF 结合口袋的、选择性的、有效的 PDK1激活剂,对其他蛋白激酶无活性。在细胞中,它的前药 PS423 可作为 PDK1的底物选择性抑制剂,抑制 S6K 的磷酸化和活化。 | |||
T3163 |
PS 48
|
PDK | PI3K/Akt/mTOR signaling |
PS 48 已被证明是一种 PKB 激酶 (PDK1) 激活剂 (Kd: 10.3 μM)。该化合物选择性地与 PKB 激酶 (PDK1) 的 PIF 结合口袋结合。 | |||
T24676 |
PS423
PS210AM,PS 210 AM,PS 423,PS210-AM,PS-423 |
||
PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site. | |||
T16671 | PS315 | PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity. PS315 is a derivative of PS48 and is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing d |