Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T81467 |
PI3Kδ-IN-18
|
PI3K | PI3K/Akt/mTOR signaling |
Se15作为PI3Kδ选择性抑制剂展现出高度效力,具有小于0.1nM的IC50值,主要应用于自身免疫反应研究领域。 | |||
T36308 |
PF-06843195
|
||
PF-06843195 is a highly selective PI3Kα inhibitor with an IC50 of 18 nM in Rat1 fibroblasts. The Kis of PF-06843195 for PI3Kα and PI3Kδ in biochemical kinase assay are less than 0.018 nM and 0.28 nM, respectively. PF-06843195 has great suppression of the PI3K/mTOR signaling pathway and durable antitumor efficacy[1]. PF-06843195 inhibits the breast cancer cell lines MCF7 and T47D proliferation with IC50s of 62 nM and 32 nM, respectively[1].PF-06843195 inhibits pAKT (T308) in MCF7 and T47D cells w... |