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Cat. No. Product Name Target Signaling Pathways
T6935 Nirogacestat

PF-03084014,PF-3084014,PF03084014,PF 03084014

Apoptosis; Gamma-secretase Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells
Nirogacestat (PF 03084014) 是一种具有口服活性的,可逆的,非竞争性的,选择性γ-secretase 抑制剂,IC50为 6.2 nM。它抑制 Notch 信号通路,可研究 Notch 受体依赖性肿瘤。
T38266 Nirogacestat dihydrobromide

Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs. Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID:20363853

化合物

Nirogacestat
Cat.No: T6935
Synonym: PF-03084014,PF-3084014,PF03084014,PF 03084014
Target: Apoptosis, Gamma-secretase
Nirogacestat dihydrobromide
Cat.No: T38266
Synonym:
Target:
TargetMol Loading
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