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Cat. No. Product Name Target Signaling Pathways
T6514 Glasdegib

PF-04449913

Hedgehog/Smoothened; Smo GPCR/G Protein; Stem Cells
Glasdegib (PF-04449913) 是一种口服具有活力的 smoothened 抑制剂,能够结合到人 SMO(181-787氨基酸位点),IC50=4 nM。
T36910 PF 04449913 maleate

Potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells. Munchhof et al (2011) Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothened. ACS Med.Chem.Lett. 3 106 PMID:24900436 |Fukushima et al (2016) Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells. Cancer Sci. 107 1422 PMID:2...

化合物

Glasdegib
Cat.No: T6514
Synonym: PF-04449913
Target: Hedgehog/Smoothened, Smo
PF 04449913 maleate
Cat.No: T36910
Synonym:
Target:
TargetMol Loading
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