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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2028 |
NG 52
NG52,NG-52,Compound 52 |
CDK | Cell Cycle/Checkpoint |
NG 52 (NG-52) 是可逆和 ATP 相容性且具有口服活性的Cdc28p 和Pho85p 激酶抑制剂,IC50分别为 7 μM 和 2 μM。它还抑制磷酸甘油酸激酶 1 的活性,IC50值为 2.5 μM。 | |||
T2447 |
AZD7545
|
Dehydrogenase | Metabolism |
AZD7545 是竞争性和选择性的PDHK2抑制剂,能够抑制PDHK1和PDHK2的活性,其IC50值分别为 36.8 nM 和 6.4 nM。 | |||
T71147 | PBS-1086 | ||
PBS-1086 is a novel dual inhibitor of the canonical and noncanonical NF-κB pathways, increasing the magnitude and duration of initial EGFR inhibitor response in multiple NSCLC models, decreasing PDHK1 expression, and suppressing phosphorylation of the PDHK1 protein substrate PDHA1 in a panel of PTEN-deficient cell lines. | |||
T63012 | TM-1 | ||
TM-1 是一种强效的丙酮酸脱氢酶激酶 (PDHK) 抑制剂,能够抑制 PDHK1 (IC50: 2.97 μM) 和 PDHK2 (IC50: 5.2 μM)的活性。TM-1 可以阻断丙酮酸脱氢酶复合物 (PDHC) 磷酸化,并抑制癌细胞增殖。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04568 |
PDK1 Protein, Human, Recombinant (His)
pyruvate dehydrogenase kinase, isozyme 1,PDHK |
Human | Baculovirus Insect Cells |
Pyruvate dehydrogenase kinase, isozyme 1, also known as [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial and PDK1, is a member of the PDK / BCKDK protein kinase family. PDK-1 is expressed predominantly in the heart. It contains one histidine kinase domain. Pyruvate dehydrogenase kinase (PDK) isoforms are molecular switches that downregulate the pyruvate dehydrogenase complex (PDC) by reversible phosphorylation in mitochondria. An inhibitory effect of lipoic acid on PDKs would... |