Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2493 |
PD 151746
|
Cysteine Protease; Proteasome | Proteases/Proteasome; Ubiquitination |
PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2]. |