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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3160	HUHS015	Others	Others
	HUHS015 是高效的PCA-1/ALKBH3抑制剂。它对 PCA-1 作用的IC50值为 0.67 μM。
T41175	OB 24 hydrochloride
	OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferationin vitroand PCA tumor growth and lymph node/lung metastasesin vivo. Synergizes with Taxol.
T78153	PSMA I&T	Others	Others
	PSMAI&T为高效的前列腺特异性膜抗原(PSMA)抑制剂，适用于前列腺癌(PCa)的单光子发射计算机断层扫描(SPECT)/计算机断层扫描(CT)显像及放射性核素研究。
T79674	HDAC-IN-64	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-64 (Compound 13) 为HDAC抑制剂，对HDAC4/6的IC50值为24 nM及85 nM。其对前列腺癌（PCA）细胞表现出抗增殖与抗迁移效果，并能抑制LNCaP和RWPE-1细胞的生长，GI50值分别达到0.32 μM与1.1 μM。
T38127	pNPS-DHA
	pNPS-DHA is an arylamide derivative of docosahexaenoyl ethanolamide that has anti-allergic activity.1It inhibits degranulation of RBL-2H3 mast cells (IC50= 15 μM).pNPS-DHA (1,000 mg/kg) inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) in mice. 1.Kim, I.-H., Kanayama, Y., Nishiwaki, H., et al.Structure-activity relationships of fish oil derivatives with anti-allergic activity in vitro and in vivoJ. Med. Chem.62(21)9576-9592(2019)

化合物

Cat. No.	Product Name	Target	Signaling Pathways
T82248	Gymnoside I
	Gymnoside I（化合物1）是糖苷氧基苄基2-异丁基苹果酸，其在小鼠被动皮肤过敏反应（PCA）实验中展现出抗过敏效能。该化合物有望在哮喘、神经衰弱和慢性肝炎治疗研究中应用。