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2

抑制剂 & 化合物

1

同位素

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Cat. No. Product Name Target Signaling Pathways
T71147 PBS-1086

Others Others
PBS-1086 is a novel dual inhibitor of the canonical and noncanonical NF-κB pathways, increasing the magnitude and duration of initial EGFR inhibitor response in multiple NSCLC models, decreasing PDHK1 expression, and suppressing phosphorylation of the PDHK1 protein substrate PDHA1 in a panel of PTEN-deficient cell lines.
T1176 Racecadotril

Acetorphan,消旋卡多曲

Neprilysin; Proteasome Metabolism; Proteases/Proteasome; Ubiquitination
Racecadotril (Acetorphan) 是一种中性内肽酶 (NEP) 抑制剂,具有止泻作用。Racecadotril 及其活性代谢物 Thiorphan 抑制小鼠脑中纯化的NEP 活性,Ki 分别为 4500 和 6.1 nM。

化合物

PBS-1086
Cat.No: T71147
Synonym:
Target: Others
Racecadotril
Cat.No: T1176
Synonym: Acetorphan,消旋卡多曲
Target: Neprilysin, Proteasome
Cat. No. Product Name Target Signaling Pathways
T71145 Racecadotril-d5

Racecadotril-d5 is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan. In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively. It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-indu...

同位素

Racecadotril-d5
Cat.No: T71145
Synonym:
Target:
TargetMol Loading
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