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Search Results for " pap1 "

Targets Recommended: Potassium Channel

2

抑制剂 & 化合物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TQ0179	PAP-1 5-(4-Phenoxybutoxy)psoralen	Potassium Channel	Membrane transporter/Ion channel
	PAP-1 (5-(4-Phenoxybutoxy)psoralen) 是口服活性的Kv1.3选择性阻滞剂 (EC50=2 nM)。它依赖性阻止 Kv1.3，并优先与通道的 C 型失活状态结合来发挥作用。
T83735	Pap12-6 TFA
	Pap12-6是一种从蝶类P. xuthus幼虫中发现的papiliocin十二个N-端氨基酸衍生的抗菌肽。它对包括E. coli、P. aeruginosa和S. syphimurium在内的八种革兰氏阴性细菌（MIC50s = 4-8 µM）以及革兰氏阳性细菌S. aureus、耐甲氧西林的S. aureus 3126（MRSA-3126）、B. subtilis和S. epidermidis（MIC50s = 4-8 µM）具有活性，但在25 µM浓度下不影响人类红细胞、小鼠RAW 264.7巨噬细胞、人类HaCaT角质形成细胞或人类HEK293肾细胞的活性。Pap12-6在4和8 µM浓度下可引起E. coli的膜去极化。Pap12-6（10 µM）预处理可降低LPS刺激的RAW 264.7巨噬细胞中一氧化氮（NO2-）、Tnf-α和Il-6的分泌水平。在体内，Pap12-6（10 mg/kg）可以提高感染E. coli的小鼠的存活率，并且在剂量为1 mg/kg时减少感染E. coli小鼠的肺、肝和肾中菌落形成单位（CFUs）的数量。Pap12-6（1 mg/kg）在E. co...

化合物

Cat.No: TQ0179

Synonym: 5-(4-Phenoxybutoxy)psoralen

Target: Potassium Channel

Cat.No: T83735

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03673	REG3B Protein, Mouse, Recombinant (His) Pap,HIP,REG-III,PAP1	Mouse	HEK293 Cells
	Expression of REG3B was sufficient to inhibit cytokine-induced activation of STAT3 in IECs. The human REG3beta protein, the functional counterpart of mouse REG3B, inhibited STAT3 activity in human 293T cells, and its expression level in colorectal tumors correlated inversely with pSTAT3 level and survival times of patients. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells. This pathway might be targeted in patients with colitis to reduce carcinogenesis.
TMPJ-01107	PAP Protein, Human, Recombinant (His) PAP1,PAP,PDGFA-Associated Protein...	Human	E. coli
	Human PAP, also known as 28 kDa heat- and acid-stable phosphoprotein, PDGF-associated protein, PDGFA-associated protein 1, PDAP1, HASPP28, is a protein which belongs to the PDAP1 family. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. PDGF-Associated Protein (PAP) is a phosphoprotein that may enhance PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. PDAP1 expression is induced by TNF-alpha, and cells overexpressing PDAP1 sho...
TMPY-01336	REG3A Protein, Human, Recombinant (His) HIP/PAP,INGAP,REG3,PAP1,PAP	Human	HEK293 Cells
	REG3A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18 kDa and the accession number is Q06141-1.
TMPY-01732	LRPAP1 Protein, Mouse, Recombinant (His) C77774,AU042172,RAP,AI790446,low density lipoprotei...	Mouse	HEK293 Cells
	LRPAP1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.4 kDa and the accession number is P55302.
TMPY-01233	LRPAP1 Protein, Human, Recombinant (His) HBP44,MYP23,low density lipoprotein receptor-related protein...	Human	HEK293 Cells
	LRPAP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.2 kDa and the accession number is P30533.
TMPH-02502	LRPAP1 Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus Insect Cells
	Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. LRPAP1 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 18.2 kDa and the accession number is P55302.

重组蛋白

REG3B Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03673

Species: Mouse

Expression System: HEK293 Cells

PAP Protein, Human, Recombinant (His)

Cat.No: TMPJ-01107

Species: Human

Expression System: E. coli

REG3A Protein, Human, Recombinant (His)

Cat.No: TMPY-01336

Species: Human

Expression System: HEK293 Cells

LRPAP1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01732

Species: Mouse

Expression System: HEK293 Cells

LRPAP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01233

Species: Human

Expression System: HEK293 Cells

LRPAP1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02502

Species: Mouse

Expression System: Baculovirus Insect Cells

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