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3

抑制剂 & 化合物

1

天然产物

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Cat. No. Product Name Target Signaling Pathways
T14007 PAF-AN-1

PAFR GPCR/G Protein
PAF-AN-1是一种新型有效的血小板激活因子受体 (PAF) 拮抗剂,参与研究过敏性死亡。
T36764 PAF C-18:1

PAF C-18:1 is a naturally occurring phospholipid produced by cells upon stimulation and plays a role in the establishment and maintenance of the inflammatory response. It is less potent than PAF C-16 and PAF C-18 in the induction of neutrophil chemotaxis, but is equipotent to PAF C-16 and PAF C-18 in promoting eosinophil migration. PAF C-18:1 activates the PAF receptor and has been used in antibody binding experiments to determine the importance of an acyl linkage at the sn-2 position for recogn...
T70882 Orlistat-d3

Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 µg/ml, respectively) but does not inhibit...

化合物

PAF-AN-1
Cat.No: T14007
Synonym:
Target: PAFR
PAF C-18:1
Cat.No: T36764
Synonym:
Target:
Orlistat-d3
Cat.No: T70882
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TN1170 1-Cinnamoylpyrrolidine

Platelet aggregation Others
1-Cinnamoylpyrrolidine 是从 Piper caninum 制备的天然产物,可作为一种 DNA 链断裂剂,在Cu2+ 存在下诱导质粒 pBR322 DNA 超螺旋的松弛。1-Cinnamoylpyrrolidine 对 PAF 诱导的血小板聚集有抑制作用,IC50 值为 37.3 μM。

天然产物

1-Cinnamoylpyrrolidine
Cat.No: TN1170
Synonym:
Target: Platelet aggregation
TargetMol Loading
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