Cat. No. | Product Name | Target | Signaling Pathways |
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T81579 |
P2X7 receptor antagonist-4
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P2X7 receptor antagonist-4(Compound 14a)是一种选择性P2X7R拮抗剂,其对人类和小鼠P2X7R的IC50值分别为64.7 nM和10.1 nM。该化合物能有效抑制NLRP3炎性体的激活,并在脓毒症模型小鼠中减少肾损伤,降低caspase-1、gasdermin D、IL-1β和IL-18的表达。 | |||
T21659 |
AZ 11645373
3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE |
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
AZ 11645373 (3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE) 是一种高度选择性和有效的人 P2X7 受体拮抗剂,对小鼠/大鼠 P2X7 受体没有影响。 | |||
T27688 |
JNJ-54166060
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JNJ-54166060 是一种 有效的 P2X7 受体 (P2X7 receptor) 拮抗剂。JNJ-54166060 对人/大鼠/小鼠 P2X7 受体作用的 IC50值分别为 4/115/72 nM。 | |||
T37313 | ITH15004 | ||
ITH15004 is a non-nucleotide antagonist of the purinergic P2X7receptor (IC50= 9 μM in HEK293 cells expressing the human receptor).1It inhibits ATP-induced currents inX. laevisoocytes expressing the human P2X7receptor when used at a concentration of 100 μM. ITH15004 (1 μM) decreases IL-1β release from LPS-primed, ATP-stimulated isolated mouse peritoneal macrophages. It has high permeability in a parallel artificial membrane permeability assay (PAMPA). 1.Calzaferri, F., Narros-Fernández, P., de Pa... |