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Cat. No. | Product Name | Target | Signaling Pathways |
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T70062 |
Osteoprotegerin
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Osteoprotegerin is a soluble secreted member of the tumor necrosis factor receptor superfamily, inhibiting osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, leading to excess accumulation of bone and cartilage. |
Cat. No. | Product Name | Species | Expression System |
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TMPJ-01466 |
Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)
OPG,Tumor Necrosis Factor Receptor Superfamily Member 11B,OC... |
Human | HEK293 Cells |
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNF... | |||
TMPY-04509 |
Osteoprotegerin Protein, Mouse, Recombinant (hFc)
tumor necrosis factor receptor superfamily member 11b,Opg,TR... |
Mouse | HEK293 Cells |
Osteoprotegerin Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 70.2 kDa and the accession number is O08712. | |||
TMPJ-00607 |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)
Receptor activator of nuclear factor κ-B ligand,Osteopro... |
Mouse | HEK293 Cells |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is BAA97257.1. | |||
TMPY-03323 |
Osteoprotegerin Protein, Rhesus, Recombinant (hFc)
tumor necrosis factor receptor superfamily member 11b,TNFRSF... |
Rhesus | HEK293 Cells |
Osteoprotegerin Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65 kDa and the accession number is G7N005. | |||
TMPY-01724 |
Osteoprotegerin Protein, Human, Recombinant (His)
OCIF,OPG,MGC29565,TR1,PDB5,tumor necrosis factor receptor su... |
Human | HEK293 Cells |
Osteoprotegerin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.3 kDa and the accession number is O00300. | |||
TMPY-05262 |
Osteoprotegerin Protein, Human, Recombinant (hFc)
MGC29565,OPG,PDB5,tumor necrosis factor receptor superfamily... |
Human | Baculovirus Insect Cells |
Osteoprotegerin Protein, Human, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 70.3 kDa and the accession number is O00300. | |||
TMPJ-00253 |
OPG Protein, Mouse, Recombinant (His)
Opg,Ocif,Tnfrsf11b,Osteoclastogenesis inhibitory factor,... |
Mouse | HEK293 Cells |
Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG ... |