Cat. No. | Product Name | Target | Signaling Pathways |
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T61800 |
OTS964
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OTS964 is a potent, orally active compound that operates as a highly selective inhibitor of TOPK with an IC 50 of 28 nM [1]. Additionally, it demonstrates significant inhibitory action against cyclin-dependent kinase CDK11, specifically binding to CDK11B with a K d of 40 nM [2]. | |||
T4135 |
OTS964 hydrochloride
OTS964 |
Apoptosis; TOPK; CDK | Apoptosis; Cell Cycle/Checkpoint; MAPK |
OTS964 hydrochloride (OTS964) 是一种口服有效的,高亲和力和选择性的 TOPK 抑制剂,IC50为 28 nM。它也是一种细胞周期蛋白依赖激酶 CDK11抑制剂,结合 CDK11B 的 Kd 值为 40 nM。 |