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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T61688	Nrf2 activator-2
	Nrf2 activator-2 (referred to as compound O15), an Osthole derivative, is a highly potent Nrf2 agonist exhibiting an EC 50 of 2.9 μM in 293 T cells. By effectively disrupting the binding between Keap1 and Nrf2, Nrf2 activator-2 activates the Nrf2 pathway. Furthermore, this compound significantly reduces the ubiquitination of Nrf2 in cells, indicating its potential in regulating Nrf2 activity [1].
T39719	Nrf2 activator-1 Nrf2 activator-1	Nrf2	Immunology/Inflammation
	Nrf2 activator-1 是一种有效的 NF-E2 相关因子 2 (Nrf2) 激活剂。Nrf2 activator-1 可用于研究包括哮喘、急性肺损伤 (ALI)、急性呼吸窘迫综合征 (ARDS) 和肺纤维化等 COPD 和其他呼吸系统疾病。
T24546	Nrf2-Activator-12G Nrf2 Activator IV,Nrf2 Activator-IV
	Nrf2-Activator-12G is a potent Nrf-2 activator.
T61522	Nrf2/HO-1 activator 2
	Nrf2/HO-1 activator 2 (compound 13m), a difluoro-substituted derivative, is a highly potent activator of Nrf2/HO-1. It exhibits substantial neuroprotective and antioxidant properties by activating the Nrf2/HO-1 pathway through phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. This compound finds utility in the investigation of Parkinson's disease (PD) [1].
T63364	Nrf2 activator-5
	Nrf2 activator-5 是 Nrf2 的有效激活剂，能够减轻 BV-2 小胶质细胞中 H2O2诱导的氧化应激和 LPS 刺激的炎症，表现出抗氧化和抗炎活作用。
T28929	TBE-31 TBE 31
	TBE-31 is a highly potent activator of Nrf2, a liver carcinogenesis blocker and a potent phase 2 cytoprotective pathway inducer.
T79484	Nrf2 activator-8
	Nrf2 activator-8（化合物 10e）作为一种效能显著的Nrf2激活剂（EC50=37.9 nM），在BV-2微神经胶质细胞中展现出优异的抗氧化及抗炎效应。此外，Nrf2 activator-8可有效逆转脂多糖（LPS）诱导的小鼠神经炎症模型中的空间记忆缺失。

化合物

Synonym: Nrf2 activator-1

Target: Nrf2

Nrf2-Activator-12G

Cat.No: T24546

Synonym: Nrf2 Activator IV,Nrf2 Activator-IV

Target:

Nrf2/HO-1 activator 2

Cat. No.	Product Name	Target	Signaling Pathways
T75635	Microcystin-LY
	Microcystin-LY 是一种铜绿微囊藻蓝藻的环状七肽毒素，可作为 Nrf2通路的激活剂引起氧化应激反应,在3μM 时诱导效果非常明显。