Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T23076 |
Nociceptin(1-7)
Nociceptin (1-7) |
Others | Others |
Bioactive metabolite of nociceptin, antagonist of nociceptin-induced hyperalgesia | |||
T23076L |
Nociceptin (1-7) acetate
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Nociceptin (1-7) acetate 是一种有效的阿片受体样受体 1 (ORL1) 受体激动剂。 Nociceptin (1-7) 与 nociceptin 结合可降低痛觉过敏并具有镇痛活性。 | |||
T75908 |
Nociceptin(1-7) TFA
|
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Nociceptin(1-7) 是 Nociceptin 的 N 端生物活性片段。Nociceptin(1-7) 是一种有效的ORL1(NOP)受体激动剂,具有缓解疼痛活性。Nociceptin(1-7) 联合 Nociceptin 可降低体内对痛觉的敏感。 | |||
TP1882L1 |
Orphanin FQ(1-11) acetate(178249-41-7 free base)
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Orphanin FQ(1-11) acetate(178249-41-7 free base) 含有 Nociceptin 氨基酸 1-11 的肽片段。 ORL1/KOR-3 受体的强效激动剂 (Ki = 55 nM);对阿片受体无亲和力,包括 μ、δ、κ1 和 κ3 受体 (Ki >1000 nM)。在 CD-1 小鼠中显示镇痛特性。 | |||
T36376 | SB-612111 | ||
SB-612111 is a novel and potent human opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). SB-612111 exhibits selectivity for μ-, κ- and δ-receptors with Ki values of 57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 effectively antagonizes the pronociceptive action of Nociceptin in an acute pain model[1]. [1]. Paola F Zaratin, et al. Modification of Nociception and Morphine Tolerance by the Selective Opiate Receptor-Like Orphan Receptor Anta... |