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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T72188	Nicotinamide Hydrochloride Niacinamide Hydrochloride,Nicotinic acid amide Hydrochloride,Niacinamide Hydrochloride ; Nicotinic acid amide Hydrochloride
	Nicotinamide Hydrochloride 是维生素 B3 或烟酸的一种形式，可抑制SIRT2的体外活性，其EC50值为 2 μM。 Nicotinamide Hydrochloride 可抑制 90% 的黑色素瘤细胞数量，并增加细胞内 NAD+、ATP、ROS 水平。Nicotinamide Hydrochloride 抑制黑色素瘤小鼠的肿瘤生长并提高生存率，可用于黑色素瘤等皮肤癌相关的研究。
T33666	Nicotinamide, N-(m-difluoromethoxyphenyl)-, hydrochloride
	Nicotinamide, N-(m-difluoromethoxyphenyl)-, hydrochloride is a bioactive chemical.
T22785	FK 866 hydrochloride (658084-64-1 free base) FK 866 hydrochloride	Others	Others
	FK 866 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (IC50: 0.09nM and 27.2nM).
T22801	GNE-617 hydrochloride (1362154-70-8 free base) GNE-617 hydrochloride	Others	Others
	GNE-617 hydrochloride is a potent and competitive inhibitor of nicotinamide phosphoribosyltransferase (IC50: 5nM). GNE-617 hydrochloride reduces the NAD levels in a > 95% reduction in both NAPRT1-deficient and NAPRT1-proficient cell lines and exerts (EC50
T40855	LB-60-OF61 hydrochloride LB-60-OF61 hydrochloride
	LB-60-OF61 hydrochloride is a highly effective inhibitor of NAMPT, a key enzyme involved in the transfer of nicotinamide phosphoribosyl groups. This compound, known for its cytotoxic properties, specifically targets cell lines that overexpress MYC, thereby demonstrating selectivity in its action.
T78164	JBSNF-000028 hydrochloride	Others	Others
	JBSNF-000028 hydrochloride为口服活性烟酰胺N-甲基转移酶(NNMT)抑制剂，对hNNMT、mkNNMT及mNNMT的IC50值分别为0.033 μM、0.19 μM和0.21 μM。
T37578	GPP 78 hydrochloride
	GPP 78 hydrochloride 是一种有效的烟酰胺磷酸核糖转移酶 (Nampt) 抑制剂，对 NAD 消耗的 IC50 为 3 nM。GPP 78 hydrochloride 通过诱导自噬对神经母细胞瘤细胞 SH-SY5Y 具有毒性，IC50 为 3.8 nM。GPP78 具有抗癌和抗炎作用。

化合物

Nicotinamide Hydrochloride

Cat.No: T72188

Synonym: Niacinamide Hydrochloride,Nicotinic acid amide Hydrochloride,Niacinamide Hydrochloride ; Nicotinic acid amide Hydrochloride

Target:

Nicotinamide, N-(m-difluoromethoxyphenyl)-, hydrochloride

Cat.No: T33666

Synonym:

Target:

FK 866 hydrochloride (658084-64-1 free base)

Cat.No: T22785

Synonym: FK 866 hydrochloride

Target: Others

GNE-617 hydrochloride (1362154-70-8 free base)

Cat.No: T22801

Synonym: GNE-617 hydrochloride

Target: Others

LB-60-OF61 hydrochloride

Cat.No: T40855

Synonym: LB-60-OF61 hydrochloride

Target:

JBSNF-000028 hydrochloride

Cat.No: T78164

Synonym:

Target: Others

GPP 78 hydrochloride

Cat.No: T37578

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T4853	TRIA-662 3-Carbamoyl-1-methylpyridinium Chloride,3-氨基甲酰-1-甲基氯化吡啶,1-Methylnicotinamide chloride,1-methylpyridin-1-ium-3-carboxamide hydrochloride,Nicotinamide Chloromethylate	Others; Endogenous Metabolite	Metabolism; Others
	TRIA-662 (Nicotinamide Chloromethylate) 是内源性代谢产物的一种。